156267-16-2Relevant articles and documents
Direct Amidation of N-Boc- and N-Cbz-Protected Amines via Rhodium-Catalyzed Coupling of Arylboroxines and Carbamates
Lim, Diane S. W.,Lew, Tedrick T. S.,Zhang, Yugen
, p. 6054 - 6057 (2015)
N-Boc- and N-Cbz-protected amines are directly converted into amides by a novel rhodium-catalyzed coupling of arylboroxines and carbamates, replacing the traditional two-step deprotection-condensation sequence. Both protected anilines and aliphatic amines are efficiently transformed into a wide variety of secondary benzamides, including sterically hindered and electron-deficient amides, as well as in the presence of acid-labile and reducible functional groups.
A catalyst-free N-benzyloxycarbonylation of amines in aqueous micellar media at room temperature
Shrikhande, Janhavi J.,Gawande, Manoj B.,Jayaram, Radha V.
, p. 4799 - 4803 (2008/12/22)
N-Benzyloxycarbonylation of amines was carried out in aqueous micellar media. Aliphatic (open and cyclic), aromatic and heteroaromatic amines react with Cbz-Cl to give excellent yields of products. The reactions were carried out in water and at room temperature.
