156276-23-2

Basic information

• Product Name: methyl (p-fluorobenzoyl)formate
• Synonyms: methyl (p-fluorobenzoyl)formate;4-Fluoro-oxo-benzeneacetic acid methyl ester
• CAS NO: 156276-23-2
• Molecular Formula: C₉H₇FO₃
• Molecular Weight: 182.1484832
• Mol File: 156276-23-2.mol
• Article Data: 39

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl (p-fluorobenzoyl)formate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (p-fluorobenzoyl)formate(156276-23-2)
• EPA Substance Registry System: methyl (p-fluorobenzoyl)formate(156276-23-2)

Safety Data

• Hazardous Substances Data: 156276-23-2(Hazardous Substances Data)

Upstream product

• 127709-19-7 methyl 4-fluoro-α-hydroxyphenylacetate 
• 5781-53-3 monomethyl oxalyl chloride 
• 352-13-6 4-flourophenylmagnesium bromide 
• 67-56-1 methanol 
• 403-43-0 4-fluorobenzoyl chloride 
• 219564-79-1 methyl 2-diazo-2-(4-fluorophenyl)acetate 
• 553-90-2 Dimethyl oxalate 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 7542-64-5 α,α-Dibromo-4'-fluoroacetophenone 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 96-36-6 methyl phosphite 
• 403-32-7 (4-fluorophenyl)glyoxal 
• 100891-10-9 methyl p-fluorocinnamate 
• 21983-80-2 1,1-dimethoxy-2-(4-fluorophenyl)-ethan-2-one 

Downstream Products

• 32222-46-1 (4-fluoro-phenyl)-hydroxy-acetic acid methyl ester 
• 63096-35-5 (4-fluoro-phenyl)-hydroxy-acetic acid methyl ester 
• 81941-86-8 6-(4-fluorophenyl)-3-methylmercapto-as-triazin-5-one 
• 125923-59-3 methyl difluoro(4-fluorophenyl)acetate 
• 60300-84-7 methyl α-benzyloxyphenylacetate 
• 1152322-66-1 C₁₉H₂₈FNO₄Si 
• 127709-19-7 methyl 4-fluoro-α-hydroxyphenylacetate 

Relevant articles and documents

Unraveling two pathways for NHPI-mediated electrocatalytic oxidation reaction

Two pathways for N-hydroxyphthalimide (NHPI)-mediated electrocatalytic oxidation using phenylacetate derivatives as template substrates were first reported for benzylic C[sbnd]H oxidation to oxygenated and non-oxygenated products. DFT calculation indicates that the hydrogen-atom transfer (HAT) process between phthalimido-N-oxyl (PINO) and substrate is a rate-determined step. Aromatic α-keto esters and 2-((1,3-dioxoisoindolin-2-yl)oxy)-2-aryl acetate obtained by cross-coupling between benzylic radical and PINO can be selectively synthesized through controlling the concentration of PINO radical. This method provides a deep understanding for selective weak C[sbnd]H oxidation using NHPI as redox mediator.

Tandem Photoredox-Chiral Phosphoric Acid Catalyzed Radical-Radical Cross-Coupling for Enantioselective Synthesis of 3-Hydroxyoxindoles

A photochemical protocol that couples diarylamines and α-ketoesters to afford the chiral 3-hydroxyoxindoles through tandem photoredox and chiral phosphoric acid catalysis is developed. The reaction involves an enantioselective photochemical radical-radical cross-coupling process. The chiral phosphoric acid is discovered to play crucial roles by decreasing the reductive potentials of α-ketoesters and stereocontrolling the downstream asymmetric radical-radical cross-coupling via the formation of pentacoordinate complex.

Visible-Light-Induced Catalyst-Free Carboxylation of Acylsilanes with Carbon Dioxide

Intermolecular carbon-carbon bond formation between acylsilanes and carbon dioxide (CO2) was achieved by photoirradiation under catalyst-free conditions. In this reaction, siloxycarbenes generated by photoisomerization of the acylsilanes added to the C═O bond of CO2 to give α-ketocarboxylates, which underwent hydrolysis to afford α-ketocarboxylic derivatives in good yields. Control experiments suggest that the generated siloxycarbene is likely to be from the singlet state (S1) of the acylsilane and the addition to CO2 is not in a concerted manner.