156353-11-6

Basic information

• Product Name: 3-methyl-3-[(3-benzyloxy-5-fluorophen-1-yl)hydroxymethyl]oxetane
• Synonyms: 3-methyl-3-[(3-benzyloxy-5-fluorophen-1-yl)hydroxymethyl]oxetane
• CAS NO: 156353-11-6
• Molecular Weight: 302.345
• Mol File: 156353-11-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-methyl-3-[(3-benzyloxy-5-fluorophen-1-yl)hydroxymethyl]oxetane(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-3-[(3-benzyloxy-5-fluorophen-1-yl)hydroxymethyl]oxetane(156353-11-6)
• EPA Substance Registry System: 3-methyl-3-[(3-benzyloxy-5-fluorophen-1-yl)hydroxymethyl]oxetane(156353-11-6)

Safety Data

• Hazardous Substances Data: 156353-11-6(Hazardous Substances Data)

Upstream product

• 99419-31-5 3-methyloxetane-3-carboxaldehyde 
• 130722-44-0 5-benzyloxy-3-fluorophenyl bromide 

Downstream Products

• 156353-12-7 3-methyl-3-[(3-benzyloxy-5-fluorophen-1-yl)oxomethyl]oxetane 

Relevant articles and documents

PHENYLMETHYL DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY

Compounds of the structure where Ar is optionally substituted carbocyclic aryl, 5- or 6-membered heterocyclic aryl, 10-membered bicyclic heterocyclic aryl containing one or two nitrogen atoms, 9- or 10-membered heterocyclic containing one or two nitrogen atoms and optionally containing a further nitrogen or oxygen atom and one oxo or thioxo substituent, benzo[b]furyl, benzo[b]thienyl, A1 is propynylene, methylene, or a valence bond, X is O, S, SO2, or NR2, Y is selected from alkyl, haloalkyl, alkoxy, halogen, and hydrogen, A2 is selected from and methylene where Z is OR5 or NHR5 where R5 is hydrogen or alkyl, R1 is hydrogen, alkyl, or OR5, and m and n are integers having a value of 1 or 2 are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states