156371-85-6

Basic information

• Product Name: (S)-3-Mercapto-pyrrolidine-1-carboxylic acid tert-butyl ester
• Synonyms: (3S)-N-Boc-3-Mercapto-1-pyrrolidine;(S)-tert-Butyl 3-Mercaptopyrrolidine-1-carboxylate
• CAS NO: 156371-85-6
• Molecular Formula: C9H17NO2S
• Molecular Weight: 203.30178
• Mol File: 156371-85-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 275.1±33.0 °C(Predicted)
• Appearance: /
• Density: 1.10±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.43±0.20(Predicted)
• CAS DataBase Reference: (S)-3-Mercapto-pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-Mercapto-pyrrolidine-1-carboxylic acid tert-butyl ester(156371-85-6)
• EPA Substance Registry System: (S)-3-Mercapto-pyrrolidine-1-carboxylic acid tert-butyl ester(156371-85-6)

Safety Data

• Hazardous Substances Data: 156371-85-6(Hazardous Substances Data)

Usage

General Description

(S)-3-Mercapto-pyrrolidine-1-carboxylic acid tert-butyl ester is a chemical compound that belongs to the class of pyrrolidine carboxylic acid esters. It is a derivative of a sulfur-containing amino acid and is commonly used in organic chemistry research and drug development. (S)-3-Mercapto-pyrrolidine-1-carboxylic acid tert-butyl ester is usually synthesized for its potential use as a building block in the production of pharmaceuticals and other organic compounds. The tert-butyl ester group in the molecule provides stability and protection for the carboxylic acid functionality, making it a versatile intermediate in organic synthesis. This chemical compound has potential applications in the fields of medicinal chemistry, drug discovery, and organic synthesis.

Upstream product

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• 101469-92-5 (S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 132945-75-6 (S)-tert-butyl 3-(methylsulfonyloxy)pyrrolidine-1-carboxylate 

Relevant articles and documents

BROAD-SPECTRUM CARBAPENEMS

The present disclosure provides broad-spectrum carbapenem derivatives and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such derivatives and/or compositions.

N-SUBSTITUTED SATURATED HETEROCYCLIC SULFONE COMPOUNDS WITH CB2 RECEPTOR AGONISTIC ACTIVITY

This invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein X, R1, R2,R3, R4, R5, R6, R7, k, m, n, p, q, r and s are each as described herein, and compositions containing such compounds, and the use of such compounds in the treatment of a condition mediated by CB2 receptor activity.

Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors

Potent SAH analogues with constrained homocysteine units have been designed and synthesized as inhibitors of human DNMT enzymes. The five membered (2S,4S)-4-mercaptopyrrolidine-2-carboxylic acid, in 1a, was a good replacement for homocysteine, while the corresponding six-member counterpart was less active. Further optimization of 1a, changed the selectivity profile of these inhibitors. A Chloro substituent at the 2-position of 1a, compound 1d, retained potency against DNMT1, while N6 alkylation, compound 7a, conserved DNMT3b2 activity. The concomitant substitutions of 1a at both 2- and N6 positions reduced activity against both enzymes.