156436-90-7

Basic information

• Product Name: Nsc695239
• Synonyms: Bis(acetato-o)[9,10-diethyl-20,21-bis[2-[2-(2-methoxyethoxy) ethoxy]ethoxy]-4,15-dimethyl-8,11-imino-6,3:13,16-dinitrilo -1,18-benzodiazacycloeicosine-5,14-dipropanolato-N1,N18,N23,N24,N25]lutetium hydrate;Lutetium texaphyrin;Nsc695239;(PB-7-11-233'2'4)-Bis(acetato-κO)[9,10-diethyl-20,21-bis[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]-4,15-diMethyl-8,11-iMino-3,6:16,13-dinitrilo-1,18-benzodiazacycloeicosine-5,14-dipropanolato-κN1,κN18,κN23,κN24,κN25]lutetiuM Hydrate
• CAS NO: 156436-90-7
• Molecular Formula: C52H74LuN5O15X+2
• Molecular Weight: 1184.13546
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 156436-90-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1059.6°Cat760mmHg
• Flash Point: 594.6°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0mmHg at 25°C
• CAS DataBase Reference: Nsc695239(CAS DataBase Reference)
• NIST Chemistry Reference: Nsc695239(156436-90-7)
• EPA Substance Registry System: Nsc695239(156436-90-7)

Safety Data

• Hazardous Substances Data: 156436-90-7(Hazardous Substances Data)

Usage

Description

Nsc695239, also known as Motexafin Lutetium Hydrate, is a synthetic metal-coordinating expanded porphyrin with diamagnetic properties. It functions as a photosensitizer that is activated using far-red light to generate cytotoxic singlet oxygen. Nsc695239 has demonstrated potential applications in various fields, including antiatherosclerotic and antineoplastic treatments.

Uses

Used in Pharmaceutical Industry:
Nsc695239 is used as an antiatherosclerotic agent for its ability to reduce the formation of atherosclerotic plaques, which are responsible for various cardiovascular diseases.
Used in Oncology:
Nsc695239 is used as an antineoplastic agent, specifically as a photosensitizer in the treatment of cancer. It is activated by far-red light, generating cytotoxic singlet oxygen that can target and destroy cancer cells.
Used in Ophthalmology:
Nsc695239 is used in the treatment of age-related macular degeneration, a leading cause of vision loss in older adults. As a photosensitizer, it can help target and destroy abnormal blood vessels in the retina, potentially preserving or improving vision in affected individuals.
Brand Names:
Nsc695239 is available under various brand names, including Lutrin (Pharmacyclics), Antrin (Pharmacyclics), and Optrin (Pharmacyclics). These products are specifically formulated for different applications and patient needs, ensuring the compound's effectiveness and safety in various medical treatments.

InChI:InChI=1/C48H66N5O10.2C2H4O2.Lu.H2O/c1-7-35-36(8-2)40-28-42-38(12-10-14-55)34(4)46(53-42)32-50-44-30-48(63-26-24-61-22-20-59-18-16-57-6)47(62-25-23-60-21-19-58-17-15-56-5)29-43(44)49-31-45-33(3)37(11-9-13-54)41(52-45)27-39(35)51-40;2*1-2(3)4;;/h27-32,54-55H,7-26H2,1-6H3;2*1H3,(H,3,4);;1H2/q-1;;;+3;/p-2/b39-27-,40-28-,41-27-,42-28-,45-31-,46-32-,49-31+,49-43+,50-32+,50-44+;;;;