156451-00-2Relevant articles and documents
A Synthetic Route to β-Hydroxytyrosine-Derived Tetramic Acids: Total Synthesis of the Fungal Metabolite F-14329
Bruckner, Sebastian,Haase, Robert G.,Schobert, Rainer
supporting information, p. 5692 - 5695 (2017/04/28)
3-Acyltetramic acids derived from β-hydroxytyrosine are synthetically challenging. The first route to this structural motif, based upon a condensation between a Meldrum's acid conjugate bearing the acyl side chain, and a β-hydroxytyrosinate, N-protected by an ortho-nitrobenzyl group is presented. This group enables the Dieckmann cyclization of the resulting N-(β-ketoacyl)amino ester, after which it can be removed photolytically without compromising the delicate 3′-hydroxy group. This strategy was applied to the first total synthesis of the fungal metabolite F-14329 (1).
Compounds for inhibiting β-amyloid peptide release and/or its synthesis
-
, (2008/06/13)
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis.
Biosynthesis of tetronasin: Part 6. Preparation of structural analogues of the diketide and triketide biosynthetic precursors to tetronasin
Less, Simon L.,Handa, Sandeep,Millburn, Karen,Leadlay, Peter F.,Dutton, Christopher J.,Staunton, James
, p. 3515 - 3518 (2007/10/03)
The preparation of three analogues of the putative diketide biosynthetic precursor (2) and eight analogues of the putative triketide biosynthetic precursor (3) of the acyl tetronic acid ionophore tetronasin, as N-acetylcysteamine thioesters (4), (5), (6), (12), (13), (14), (15), (22), (23), (24) and (25) is described. Five examples are 19F-labelled; a new, enantiospecific method for the creation of a fluorinated quarternary α-centre is presented.