1566-15-0

Basic information

• Product Name: PHOSPHORAMIDEMUSTARD
• Synonyms: Ai3-51834;Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-, compd. with cyclohexanamine(1:1) (9ci);Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-, compound with cyclohexanamine (1:1);N,N-Bis(2-chloroethyl)phosphorodiaMidic Acid CyclohexylaMine Salt
• CAS NO: 1566-15-0
• Molecular Formula: C₄H₁₁Cl₂N₂O₂P*C₆H₁₃N
• Molecular Weight: 320.196221
• Product Categories: Amino Acids & Derivatives, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1566-15-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 363.5°Cat760mmHg
• Flash Point: 173.6°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 2.84E-06mmHg at 25°C
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Stability: Moisture Sensitive
• CAS DataBase Reference: PHOSPHORAMIDEMUSTARD(CAS DataBase Reference)
• NIST Chemistry Reference: PHOSPHORAMIDEMUSTARD(1566-15-0)
• EPA Substance Registry System: PHOSPHORAMIDEMUSTARD(1566-15-0)

Safety Data

• Hazardous Substances Data: 1566-15-0(Hazardous Substances Data)

Usage

Description

PHOSPHORAMIDEMUSTARD, also known as N,N-Bis(2-chloroethyl)phosphorodiamidic Acid Cyclohexylamine Salt, is a cytotoxic metabolite derived from Cyclophosphamide (C988580). It is a chemical compound with significant biological activity, primarily recognized for its role in the pharmaceutical industry due to its cytotoxic properties.

Uses

Used in Pharmaceutical Industry:
PHOSPHORAMIDEMUSTARD is used as a cytotoxic agent for its ability to inhibit cell growth and proliferation, making it a crucial component in the development of cancer treatments. Its cytotoxic nature allows it to target and destroy cancer cells, thus playing a vital role in the treatment of various types of cancer.
Used in Cancer Treatment:
PHOSPHORAMIDEMUSTARD is utilized as a chemotherapeutic agent for its effectiveness in treating a wide range of cancers. It is particularly useful in the treatment of solid tumors, such as those found in the breast, lung, and ovaries, as well as leukemia and lymphoma. The compound works by disrupting the DNA of cancer cells, preventing them from dividing and spreading.
Used in Research and Development:
In addition to its direct application in cancer treatment, PHOSPHORAMIDEMUSTARD is also used as a research tool in the development of new cancer therapies. Its cytotoxic properties make it a valuable compound for studying the mechanisms of cell death and the development of resistance to chemotherapy in cancer cells. This research can lead to the discovery of new drugs and treatment strategies to combat cancer more effectively.

InChI:InChI=1/C6H13N.C4H11Cl2N2O2P/c7-6-4-2-1-3-5-6;5-1-3-8(4-2-6)11(7,9)10/h6H,1-5,7H2;1-4H2,(H3,7,9,10)

Downstream Products

• 83182-93-8 N,N-bis(5-hydroxy-3-thiapentyl)phosphorodiamidic acid cyclohexylammonium salt 
• 3890-98-0 monohydroxy nornitrogen mustard 
• 334-22-5 N,N-bis(chloro-2-ethyl)amine 

Relevant articles and documents

Novel antitumor aldophosphamide analogs

A compound having the structure: STR1 wherein R is CH3, C2 H5, C3 H7, t--C4 H9 or C6 H5 ; R1 is NH2, NHCH3, NHC2