156746-77-9 Usage
Description
2-Chloro-4-iodo-6-Methylbenzenamine is an organic compound characterized by its chloro, iodo, and methyl substituents on the benzene ring. It is a versatile intermediate in the synthesis of various chemical compounds and has potential applications in the pharmaceutical and chemical industries due to its unique structural features.
Uses
Used in Pharmaceutical Industry:
2-Chloro-4-iodo-6-Methylbenzenamine is used as a reactant for the preparation of vanilloid receptor antagonists. These antagonists are important in the development of drugs targeting pain relief and other therapeutic applications related to the modulation of vanilloid receptors.
Used in Chemical Synthesis:
In the chemical industry, 2-Chloro-4-iodo-6-Methylbenzenamine serves as a key intermediate in the synthesis of a variety of complex organic molecules. Its unique functional groups allow for further chemical reactions, making it a valuable building block for creating new compounds with specific properties and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 156746-77-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,6,7,4 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 156746-77:
(8*1)+(7*5)+(6*6)+(5*7)+(4*4)+(3*6)+(2*7)+(1*7)=169
169 % 10 = 9
So 156746-77-9 is a valid CAS Registry Number.
156746-77-9Relevant articles and documents
Aromatic iodination with the I2-HgX2 combination
Bachki, Abderrazak,Foubelo, Francisco,Yus, Miguel
, p. 5139 - 5146 (2007/10/02)
The reaction of differnt aromatic compounds 1a-1t with iodine and a mercury(II)-salt 2 [mercury(II) chloride, nitrate or triflate] (1:1:1 molar ratio) in dichloromethane at room temperature leads to the corresponding iodoarene 3, the obtained regiochemistry being the expected. Concerning the mercury(II) salt, the observed reactivity decreased in the series triflate > nitrate > chloride according to their ionic character. An activation of the iodine molecule by the mercury(II) salt followed by a S(E) reaction with the aromatic compounds is postulated as the possible mechanism.
