15686-51-8 Usage
Description
CLEMASTINE FUMARATE is an antihistamine drug with antimuscarinic and moderate sedative properties. It is used in its fumarate salt form for the symptomatic relief of various allergic conditions.
Uses
Used in Pharmaceutical Industry:
CLEMASTINE FUMARATE is used as an antihistaminic for the treatment of allergy symptoms, rhinites, Quinke’s edema, anaphylactic shock, hay fever, allergic dermatitis and dermatosis, and chronic eczema.
Used in Allergy Treatment:
CLEMASTINE FUMARATE is used as a medication for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis, and pruritic (severe itching) skin conditions.
Brand names of CLEMASTINE FUMARATE include Tavist (Novartis), Aller-ez plus, Alogynan, Antihist-1, Arrest, Benaznyl, Clemastin fumarate syrup, Corto-tavegil, Dexa-tavegil, Fumarsutin, Licasol, Maikohist, Mallermin, Rhinorgal tavegil, Tavist 1, Tavist tablets, Tavist-1, Tavist-d, and Tavist-syrup.
Therapeutic Function
Antihistaminic
Clinical Use
Antihistamine:
Symptomatic relief of allergy such as hay fever,
urticaria
Synthesis
Clemastine, 2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine
(16.1.4), is synthesized by reacting 1-(4-chlorophenyl)-1-phenylethanol (16.1.3) with 2-
(2-chlorethyl)-2-methylpyrrolidine using sodium amide as a base. The starting
1-(4-chlorophenyl)-1-phenylethanol (16.1.3) is synthesized either by reacting 4-chlorobenzophenone
with methylmagnesium chloride, or by reacting 4-chloroacetophenone with
phenylmagnesium bromide.
Drug interactions
Potentially hazardous interactions with other drugs
Analgesics: sedative properties increased with opioid
analgesics.
Metabolism
Extensively metabolised in the liver mainly by mono- and
didemethylation and glucuronide conjugation.
The metabolites are mainly excreted in the urine.
Check Digit Verification of cas no
The CAS Registry Mumber 15686-51-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,6,8 and 6 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 15686-51:
(7*1)+(6*5)+(5*6)+(4*8)+(3*6)+(2*5)+(1*1)=128
128 % 10 = 8
So 15686-51-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1
