1569-11-5

Basic information

• Product Name: 2-Hydroxy-7-methyl-1,8-naphthyridine
• Synonyms: 2-Hydroxy-7-methyl-1,8-naphthyridine;7-methyl-1,8-naphthyridin-2-ol
• CAS NO: 1569-11-5
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160
• Mol File: 1569-11-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Hydroxy-7-methyl-1,8-naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-7-methyl-1,8-naphthyridine(1569-11-5)
• EPA Substance Registry System: 2-Hydroxy-7-methyl-1,8-naphthyridine(1569-11-5)

Safety Data

• Hazardous Substances Data: 1569-11-5(Hazardous Substances Data)

Upstream product

• 1568-93-0 2-amino-7-methyl-1,8-naphthyridine 
• 141-86-6 2.6-diaminopyridine 
• 127446-39-3 2-<(2,2-Dimethyl-1-oxopropyl)amino>-β-hydroxy-6-methyl-3-pyridinepropanoic Acid, 1,1-Dimethylethyl Ester 
• 86847-79-2 2,2-dimethyl-N-(6-methylpyridin-2-yl)propanamide 
• 127446-32-6 2,2-Dimethyl-N-(3-formyl-6-methyl-2-pyridinyl)propanamide 
• 1824-81-3 2-Amino-6-methylpyridine 

Downstream Products

• 130276-98-1 7-(bromomethyl)-1,8-naphthyridin-2-one 
• 959616-99-0 7-methyl-3,4-dihydro-1,8-naphthyridin-2(1H)-one 
• 959617-00-6 7-oxo-7,8-dihydro-1,8-naphthyridine-2-carbaldehyde 

Relevant articles and documents

1,8-Naphthyridinecarbaldehydes and Their Methyl-Substituted Precursors: Synthesis, Molecular Structures, Supramolecular Motifs and Trapped Water Clusters

1,8-Naphthyridinecarbaldehydes bearing chlorine, pyrrolidinyl, piperidinyl or morpholinyl groups, were synthesised by oxidation of their methyl-substituted precursors. The prepared carbaldehydes represent valuable starting materials for the construction of systems that are useful for supramolecular and medicinal chemistry. Single-crystal X-ray diffraction studies of four carbaldehydes and six methyl derivatives provided interesting information about the supramolecular motifs in the crystal structures of solvent-free and solvated naphthyridines. The formation of interesting water clusters, for example, T4(2) water tape, was observed in the case of 7-methyl-2-(piperidin-1-yl)-1,8-naphthyridine as well as in the crystal structure of a by-product 7-(morpholin-1-yl)-1,8-naphthyridine-2-carboxylic acid. Knowledge of the detailed structural properties of water clusters is of great research interest to a broad range of scientific disciplines.

A ratiometric fluorescent probe for the detection of hydroxyl radicals in living cells

A naphthalimide-naphthyridine derivative has been synthesized for the detection of hydroxyl radicals. It can distinguish hydroxyl radicals from other reactive oxygen species with high selectivity and short response time. Moreover, it has no cellular toxicity, and can be effectively used for intracellular detection of hydroxyl radicals. The Royal Society of Chemistry 2014.

Pyridine and related aza heterocycle derivatives as cardiovascular agents

Novel pharmaceutical compounds and compositions having nitrogen containing ring systems which may be represented by the following structural formula: wherein R1 or R3 is a moiety of the formula: wherein R6 is selected from either hydrogen or acetyl; R7 is selected from 2, 3 or 4-pyridyl or 1-imidazolyl and Q is -(CH2)n, where n is an integer from 1 to 5 and R1 and R2, R2 and R3, R3 and R4 or R4 and R5 taken together may be -CH=CH-CH=CH-. The compounds and compositions are useful as inhibitors of thromboxane synthetase and in the treatment of hypertension and arrythmia in mammals.