1569975-46-7

Basic information

• Product Name: 4-(1-(2-(1H-indol-3-yl)ethyl)-4-hydroxy-3-nicotinoyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzamide
• Synonyms: 4-(1-(2-(1H-indol-3-yl)ethyl)-4-hydroxy-3-nicotinoyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzamide
• CAS NO: 1569975-46-7
• Molecular Weight: 466.496
• Mol File: 1569975-46-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(1-(2-(1H-indol-3-yl)ethyl)-4-hydroxy-3-nicotinoyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-(2-(1H-indol-3-yl)ethyl)-4-hydroxy-3-nicotinoyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzamide(1569975-46-7)
• EPA Substance Registry System: 4-(1-(2-(1H-indol-3-yl)ethyl)-4-hydroxy-3-nicotinoyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzamide(1569975-46-7)

Safety Data

• Hazardous Substances Data: 1569975-46-7(Hazardous Substances Data)

Upstream product

• 619-66-9 4-Carboxybenzaldehyde 
• 61-54-1 tryptamine 
• 778531-36-5 (Z)-ethyl 2-hydroxy-4-oxo-4-(pyridin-3-yl)but-2-enoate 
• 6051-41-8 4-formylbenzamide 
• 350-03-8 methyl-3-pyridylketone 

Relevant articles and documents

Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators

NMDA receptors are tetrameric complexes composed of GluN1 and GluN2A-D subunits that mediate a slow Ca2+-permeable component of excitatory synaptic transmission. NMDA receptors have been implicated in a wide range of neurological diseases and thus represent an important therapeutic target. We herein describe a novel series of pyrrolidinones that selectively potentiate only NMDA receptors that contain the GluN2C subunit. The most active analogues tested were over 100-fold selective for recombinant GluN2C-containing receptors over GluN2A/B/D-containing NMDA receptors as well as AMPA and kainate receptors. This series represents the first class of allosteric potentiators that are selective for diheteromeric GluN2C-containing NMDA receptors.