157024-75-4 Usage
Description
1-(3,5-BIS-O-(TETRAHYDRO-2H-PYRAN-2-YL)-BETA-D-ARABINOFURANOSYL)-2,4(1H,3H)-PYRIMIDINEDIONE is a pyrimidine nucleoside analog, a complex chemical compound that resembles the building blocks of nucleic acids such as DNA and RNA. This molecule features a pyrimidine base (2,4(1H,3H)-pyrimidinedione) connected to a sugar molecule (beta-D-arabinofuranosyl) with two tetrahydro-2H-pyran-2-yl groups. Its intricate structure and potential applications in medicinal chemistry and drug development make it a compound of interest, particularly in the development of antiviral or antitumor agents.
Uses
Used in Pharmaceutical Industry:
1-(3,5-BIS-O-(TETRAHYDRO-2H-PYRAN-2-YL)-BETA-D-ARABINOFURANOSYL)-2,4(1H,3H)-PYRIMIDINEDIONE is used as a potential antiviral or antitumor agent for its ability to interfere with nucleic acid synthesis and replication. Its complex structure and potential side effects, however, make it a challenging molecule to work with, and further research is likely needed to fully understand its properties and potential uses.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1-(3,5-BIS-O-(TETRAHYDRO-2H-PYRAN-2-YL)-BETA-D-ARABINOFURANOSYL)-2,4(1H,3H)-PYRIMIDINEDIONE serves as a subject of study for understanding its interactions with biological targets and its potential as a therapeutic agent. Its complex structure provides a basis for exploring novel mechanisms of action and developing new drug candidates with improved efficacy and safety profiles.
Used in Drug Development:
1-(3,5-BIS-O-(TETRAHYDRO-2H-PYRAN-2-YL)-BETA-D-ARABINOFURANOSYL)-2,4(1H,3H)-PYRIMIDINEDIONE is utilized in drug development as a starting point for designing new molecules with potential antiviral or antitumor activities. Its unique structure may offer insights into the development of more effective and targeted therapies for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 157024-75-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,0,2 and 4 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 157024-75:
(8*1)+(7*5)+(6*7)+(5*0)+(4*2)+(3*4)+(2*7)+(1*5)=124
124 % 10 = 4
So 157024-75-4 is a valid CAS Registry Number.
157024-75-4Relevant articles and documents
SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY OF 2'-O-ALLYL-1-beta-D-ARABINOFURANOSYL-URACIL, -CYTOSINE AND -ADENINE
Manfredini, Stefano,Baraldi, Pier Giovanni,Bazzanini, Rita,Simoni, Daniele,Balzarini, Jan,Clercq, Erik De
, p. 473 - 478 (1997)
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3-methyl uridine and 4-methyl cytidine nucleoside compound, synthetic method and its pharmaceutical use
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, (2016/10/08)
The invention discloses a 3-methyluridine and 4-methylcytidine nucleosides compound and a synthesis method and pharmaceutical application thereof, belonging to the field of medicinal chemistry. The compound has a structural formula as shown in the specification. The compound has the effects of simultaneously modifying sugar rings and basic groups, increasing the activity of the compound and reducing the toxicity, provides a good application prospect for development of like medicines and can be applied to preparation of anti-HBV (Hepatitis B virus) medicines. The synthesis method is simple and feasible and provides conditions for mass synthesis of the compound.
Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors
Manfredini, Stefano,Baraldi, Pier G.,Durini, Elisa,Porcu, Luca,Angusti, Angela,Vertuani, Silvia,Solaroli, Nicola,De Clercq, Erik,Karlsson, Anna,Balzarini, Jan
, p. 1329 - 1332 (2007/10/03)
Highly selective arabinofuranosyl nucleosides, which inhibit the mitochondrial thymidine kinase (TK-2) without affecting the closely related herpes simplex virus type 1 thymidine kinase (HSV-1 TK), varicella-zoster virus thymidine kinase (VZV-TK), cytosolic thymidine kinase (TK-1) or the multifunctional Drosophila melanogaster deoxyribonucleoside kinase (Dm-dNK), have been obtained. SAR studies indicate a close relation between the length of the substituent at the 2′ position of the arabinofuranosyl moiety and the inhibitory activity.