157026-18-1

Basic information

• Product Name: 2-Amino-5-Bromo-3-Nitrobenzotrifluoride
• Synonyms: 2-Amino-5-Bromo-3-Nitrobenzotrifluoride;4-Bromo-2-nitro-6-(trifluoromethyl)aniline;4-Bromo-2-nitro-6-(trifluoromethyl)aniline, 2-Amino-5-bromo-3-(trifluoromethyl)nitrobenzene;4-bromo-2-nitro-6-(trifluoromethyl)Benzenamine
• CAS NO: 157026-18-1
• Molecular Formula: C₇H₄BrF₃N₂O₂
• Molecular Weight: 285.03
• Product Categories: Trifluoromethylbenzene serise
• Mol File: 157026-18-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 273.474 °C at 760 mmHg
• Flash Point: 119.193 °C
• Appearance: /Solid
• Density: 1.859 g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: -3.75±0.25(Predicted)
• CAS DataBase Reference: 2-Amino-5-Bromo-3-Nitrobenzotrifluoride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-Bromo-3-Nitrobenzotrifluoride(157026-18-1)
• EPA Substance Registry System: 2-Amino-5-Bromo-3-Nitrobenzotrifluoride(157026-18-1)

Safety Data

• Hazardous Substances Data: 157026-18-1(Hazardous Substances Data)

Usage

Description

2-Amino-5-Bromo-3-Nitrobenzotrifluoride is an organic compound characterized by its unique molecular structure, which features a benzene ring with a trifluoromethyl group, a nitro group, a bromine atom, and an amino group attached at different positions. 2-Amino-5-Bromo-3-Nitrobenzotrifluoride is known for its potential applications in various chemical and pharmaceutical processes due to its versatile functional groups.

Uses

Used in Pharmaceutical Industry:
2-Amino-5-Bromo-3-Nitrobenzotrifluoride is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its unique structure allows it to be a key component in the synthesis of drugs targeting specific receptors or enzymes in the human body.
Used in Chemical Research:
In the field of chemical research, 2-Amino-5-Bromo-3-Nitrobenzotrifluoride serves as a valuable compound for studying the effects of different functional groups on the properties and reactivity of organic molecules. It can be used to explore new reaction pathways and develop innovative synthetic methods.
Used in the Synthesis of TRPM8 Antagonists:
2-Amino-5-Bromo-3-Nitrobenzotrifluoride is used as a reagent for the preparation of 3-(5-arylbenzimidazol-2-yl)-1-oxa-2-azaspiro[4.5]decenes, which are transient receptor potential melastatin 8 (TRPM8) antagonists. These antagonists have potential applications in the treatment of painful conditions related to cold, providing a new avenue for pain management and relief.

InChI:InChI=1/C7H4BrF3N2O2/c8-3-1-4(7(9,10)11)6(12)5(2-3)13(14)15/h1-2H,12H2

Upstream product

• 179062-00-1 N-(4-bromo-2-nitro-6-trifluoromethyl-phenyl)-acetamide 
• 445-02-3 4-bromo-2-trifluoromethyl-aniline 
• 29124-62-7 N-(4-bromo-2-trifluoromethyl-phenyl)-acetamide 
• 105172-74-5 3-bromo-5-nitro-6-chlorobenzotrifluoride 
• 1155800-52-4 N-(4-bromo-2-nitro-6-(trifluoromethyl)phenyl)-2,2,2-trifluoroacetamide 
• 24821-17-8 2-Nitro-6-(trifluoromethyl)aniline 

Downstream Products

• 157026-19-2 5-bromo-3-(trifluoromethyl)-1,2-benzenediamine 
• 1221349-79-6 3-[5-(2-fluorophenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene 
• 1259026-96-4 3-[5-(2-fluorophenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride 
• 1221349-77-4 3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene 
• 1259026-98-6 3-[5-(2-trifluoromethoxyphenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride 
• 1221349-56-9 3-[5-(2-chlorophenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene 
• 1259027-00-3 3-[5-(2-chlorophenyl)-7-trifluoromethyl-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene hydrochloride 
• 1276127-39-9 C₂₂H₁₇F₆N₃O₅ 
• 1221349-68-3 3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1,8-dioxa-2-azaspiro[4.5]dec-2-ene 
• 1221349-53-6 3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene 
• 1259026-14-6 JNJ-41876666 
• 1276127-20-8 C₂₂H₂₁F₄N₃O₂ 
• 1276127-33-3 C₂₂H₂₁F₄N₃O₂ 
• 1276127-34-4 C₂₃H₂₁F₆N₃O₃ 

Relevant articles and documents

BENZIMIDAZOLE ANTIVIRAL AGENTS

Provided are compounds of Formula (I) and (II) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).

An efficient synthetic process for scale-up production of 4,5-diamino-2- (trifluoromethyl)benzonitrile and 5-bromo-3-(trifluoromethyl)benzene-1,2-diamine

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