157065-36-6

Basic information

• Product Name: N-α-tert-butoxycarbonyl-N-3,5-bis(trifluoromethyl)benzyltryptophan amide
• Synonyms: N-α-tert-butoxycarbonyl-N-3,5-bis(trifluoromethyl)benzyltryptophan amide
• CAS NO: 157065-36-6
• Molecular Weight: 529.482
• Mol File: 157065-36-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-α-tert-butoxycarbonyl-N-3,5-bis(trifluoromethyl)benzyltryptophan amide(CAS DataBase Reference)
• NIST Chemistry Reference: N-α-tert-butoxycarbonyl-N-3,5-bis(trifluoromethyl)benzyltryptophan amide(157065-36-6)
• EPA Substance Registry System: N-α-tert-butoxycarbonyl-N-3,5-bis(trifluoromethyl)benzyltryptophan amide(157065-36-6)

Safety Data

• Hazardous Substances Data: 157065-36-6(Hazardous Substances Data)

Upstream product

• 13139-14-5 Boc-Trp-OH 
• 85068-29-7 3,5-bis-trifluoromethylbenzylamine 

Downstream Products

• 500725-28-0 {5-[1-(3,5-bis-trifluoromethyl-benzylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-pyrrolidin-2-ylidene}-acetic acid methyl ester 

Relevant articles and documents

Novel potent substance P and neurokinin A receptor antagonists. Conception, synthesis and biological evaluation of indolizine derivatives

Exploration of SAR around dual NK1/NK2 antagonist Cbz-Gly-Leu-Trp-OBzl(CF3)2 and its derivatives disclosed the essential requirements for more potent dual NK1/NK2 binding. We report here the synthesis and the biological properties of a novel series of indolizine including pharmacophoric elements.