15707-30-9Relevant articles and documents
Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors
Hosoya, Yusuke,Imanishi, Miki,Kii, Isao,Nojo, Wataru,Ohkanda, Junko,Suzuki, Takanori
, p. 11203 - 11206 (2020)
Essential components of the human circadian clock, BMAL1 and CLOCK, which are intrinsically disordered transcription factors, were expressed and subjected to a fluorescentin vitrobinding assay using an E-box DNA fragment. Screening of a chemical library identified 5,8-quinoxalinedione (1), which was found to inhibit binding of the heterodimer BMAL1/CLOCK to E-box at low micromolar concentrations.