1571082-13-7

Basic information

• Product Name: C₁₈H₁₇N₂O⁽¹⁺⁾
• CAS NO: 1571082-13-7
• Molecular Weight: 277.346
• Mol File: 1571082-13-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₇N₂O⁽¹⁺⁾(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₇N₂O⁽¹⁺⁾(1571082-13-7)
• EPA Substance Registry System: C₁₈H₁₇N₂O⁽¹⁺⁾(1571082-13-7)

Safety Data

• Hazardous Substances Data: 1571082-13-7(Hazardous Substances Data)

Upstream product

• 51451-05-9 chloroacetaldoxime 
• 24667-94-5 2-(4-methylphenyl)quinoline 

Relevant articles and documents

Targeting abasic site-containing DNA with annelated quinolizinium derivatives: The influence of size, shape and substituents

The interactions of regular DNA and abasic site-containing DNA (AP-DNA) with quinolizinium (1a), the linearly fused benzo[b]quinolizinium (2a), the angularly fused benzo[a]quinolizinium (3a), benzo[c]quinolizinium (4a), and dibenzo[a,f]quinolizinium (5a) as well as derivatives thereof were studied with photometric and viscosimetric titrations (regular DNA), fluorimetric titrations and thermal DNA denaturation experiments (regular DNA and AP-DNA). Whereas the parent quinolizinium ion (1a) and the benzo-annelated derivatives 2a, 3a and 4a exhibit no significant affinity to AP-DNA, additional benzo-annelation in 5a leads to an increased selective stabilization of AP-DNA by this ligand. Hence, the latter compound represents the first example of a ligand that does not require ancillary substituents for efficient AP-DNA stabilization. In addition, studies of derivatives with varied substitution patterns revealed an impact of substituents on the stabilization of the AP-DNA. We discovered that a chloro substituent affects the propensity of a ligand to bind to AP-DNA in a similar way as the methyl substituent and may be employed complementary to the known methyl effect to increase the binding affinity of a ligand.