1572185-50-2

Basic information

• Product Name: 2-bromo-4-fluoro-6-methylphenol
• Synonyms: 2-bromo-4-fluoro-6-methylphenol
• CAS NO: 1572185-50-2
• Molecular Weight: 205.026
• Mol File: 1572185-50-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-bromo-4-fluoro-6-methylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-4-fluoro-6-methylphenol(1572185-50-2)
• EPA Substance Registry System: 2-bromo-4-fluoro-6-methylphenol(1572185-50-2)

Safety Data

• Hazardous Substances Data: 1572185-50-2(Hazardous Substances Data)

Usage

General Description

2-bromo-4-fluoro-6-methylphenol is a chemical compound with the molecular formula C7H6BrFO. It is a derivative of phenol and contains bromine, fluorine, and methyl groups. 2-bromo-4-fluoro-6-methylphenol is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in organic synthesis and in the production of dyes and pigments. 2-bromo-4-fluoro-6-methylphenol is known for its antimicrobial and antifungal properties, and it is used in various industrial and medical applications. Due to its potential hazards, it should be handled and stored in accordance with appropriate safety guidelines.

Upstream product

• 452-72-2 4-fluoro-2-methylphenol 

Downstream Products

• 245762-35-0 5-fluoro-2,3-dihydrobenzofuran 
• 1572185-25-1 2-(4-fluoro-2-methyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide 
• 1572185-24-0 methyl 2-(4-fluoro-2-methyl-6-(tetrahydrofuran-3-yl)phenoxy)acetate 
• 1572185-47-7 4-fluoro-2-methyl-6-(tetrahydrofuran-3-yl)phenol 
• 1572184-66-7 (E)-N’-((1H-indol-4-yl)methylene)-2-(4-fluoro-2-methyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide 
• 1572184-65-6 (E)-N’-((1H-indol-6-yl)methylene)-2-(4-fluoro-2-methyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide 
• 1572185-31-9 4-fluoro-2-(furan-3-yl)-6-methylphenol 

Relevant articles and documents

Preparation method of 2-bromo-4-fluoro-6-methylphenol

The invention discloses a preparation method of 2-bromo-4-fluoro-6-methylphenol, and belongs to the technical field of fine chemical engineering. The preparation method of 2-bromo-4-fluoro-6-methylphenol comprises the following steps of: (1) diazotization hydrolysis reaction: carrying out diazotization hydrolysis reaction on 2-methyl-4-fluoroaniline to obtain 2-methyl-4-fluorophenol; and (2) bromination reaction: carrying out bromination reaction on the 2-methyl-4-fluorophenol prepared in the step (1) to prepare the 2-bromo-4-fluoro-6-methylphenol. According to the method, nitrosyl sulfuric acid is adopted as an acylation reagent, waste acid obtained after diazotization hydrolysis is completed does not contain salt, acidic wastewater is easy to treat, and industrial production is facilitated; bromine used in the bromination reaction is greatly reduced, and the technological process is more environmentally friendly.

Redox-Neutral Coupling between Two C(sp3)?H Bonds Enabled by 1,4-Palladium Shift for the Synthesis of Fused Heterocycles

The intramolecular coupling of two C(sp3)?H bonds to forge a C(sp3)?C(sp3) bond is enabled by 1,4-Pd shift from a trisubstituted aryl bromide. Contrary to most C(sp3)?C(sp3) cross-dehydrogenative couplings, this reaction operates under redox-neutral conditions, with the C?Br bond acting as an internal oxidant. Furthermore, it allows the coupling between two moderately acidic primary or secondary C?H bonds, which are adjacent to an oxygen or nitrogen atom on one side, and benzylic or adjacent to a carbonyl group on the other side. A variety of valuable fused heterocycles were obtained from easily accessible ortho-bromophenol and aniline precursors. The second C?H bond cleavage was successfully replaced with carbonyl insertion to generate other types of C(sp3)-C(sp3) bonds.