15724-70-6

Basic information

• Product Name: N,N'-acridine-3,6-diyldi(acetamide)
• Synonyms: N,N'-acridine-3,6-diyldi(acetamide);3,6-Bis(acetylamino)acridine;N,N'-Acridine-3,6-diylbisacetamide
• CAS NO: 15724-70-6
• Molecular Formula: C17H15N3O2
• Molecular Weight: 293.3199
• EINECS: 239-819-5
• Mol File: 15724-70-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 270 °C
• Boiling Point: 673.9°Cat760mmHg
• Flash Point: 361.4°C
• Appearance: /
• Density: 1.351g/cm³
• PKA: 13.12±0.43(Predicted)
• CAS DataBase Reference: N,N'-acridine-3,6-diyldi(acetamide)(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-acridine-3,6-diyldi(acetamide)(15724-70-6)
• EPA Substance Registry System: N,N'-acridine-3,6-diyldi(acetamide)(15724-70-6)

Safety Data

• Hazardous Substances Data: 15724-70-6(Hazardous Substances Data)

Usage

General Description

N,N'-acridine-3,6-diyldi(acetamide) is a chemical compound with the molecular formula C20H18N2O2. It consists of a central acridine ring with two acetamide groups attached at the 3 and 6 positions. N,N'-acridine-3,6-diyldi(acetamide) is often used in organic synthesis and medicinal chemistry as a building block for the preparation of various derivatives and analogs. It has been studied for its potential biological activity and has shown promising results in antimicrobial, antitumor, and antiviral applications. The unique structure of N,N'-acridine-3,6-diyldi(acetamide) makes it a valuable tool for the development of novel pharmaceuticals and bioactive compounds.

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Downstream Products

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Relevant articles and documents

New α,ω-Diamido and α,ω-Diamino Mono- and Bi-Bridged Acridine Dimers

A novel set of dimers derived from 9-amino acridine was prepared and characterized by 1H and 13C NMR.These derivatives are bridged at several different positions of the heterocyclic moieties, by the way of α,ω-diamide or α,ω-diamino side-chains.Additionally the preparation of some bi-bridged compounds was achieved. Keywords. 9-Amino-acridine; Mono-bridged dimers; Bi-bridged dimers;

Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine

Two new series of diaminoacridinic derivatives obtained from proflavine and N-(6-amino-3-acridinyl)acetamide were synthesised and assessed for their cytotoxic and antileishmanial activities. Two compounds, N-[6-(acetylamino)-3-acridinyl]acetamide and N-[6-(benzoylamino)-3-acridinyl]benzamide demonstrated highly specific antileishmanial properties against the intracellular amastigote form of the parasite. Structure-activity relationships established that the antiproliferative activity against human cells was greatly enhanced by the presence of a benzoylamino group in 6-mono-substituted acridines, while the presence of two acetylamino or benzoylamino groups in 3,6-di-substituted acridines strongly increased the specificity of the molecules for Leishmania parasite, suggesting that symmetric conformations could preferentially interfere with Leishmania metabolism.