15725-53-8

Basic information

• Product Name: Benzoic acid, 4-(2,2-dicyanoethenyl)-
• Synonyms: benzylidenemalononitrile (BMN) deriv. 12;2-(4-Carboxy-benzyliden)-malonsaeure-dinitril;4-Carboxybenzylidenmalonitril;Benzoic acid,4-(2,2-dicyanoethenyl)
• CAS NO: 15725-53-8
• Molecular Formula: C11H6N2O2
• Molecular Weight: 198.181
• Mol File: 15725-53-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 190 °C
• Boiling Point: 431.1±35.0 °C(Predicted)
• Density: 1.357±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzoic acid, 4-(2,2-dicyanoethenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(2,2-dicyanoethenyl)-(15725-53-8)
• EPA Substance Registry System: Benzoic acid, 4-(2,2-dicyanoethenyl)-(15725-53-8)

Safety Data

• Hazardous Substances Data: 15725-53-8(Hazardous Substances Data)

Upstream product

• 619-66-9 4-Carboxybenzaldehyde 
• 109-77-3 malononitrile 

Downstream Products

• 1270162-35-0 C₁₆H₁₂N₂O₂ 
• 333963-69-2 4-(6-amino-3,5-dicyano-2-thioxo-1,2-dihydro-pyridin-4-yl)-benzoic acid 

Relevant articles and documents

A novel eco-friendly process for the synthesis of 2- chlorobenzylidenemalononitrile and its analogues using water as a solvent

A simple and novel eco-friendly process for the synthesis of 2-chlorobenzylidene malononitrile (CS) and their analogues in water using 1-methyl imidazole (catalyst) has been developed. The reaction conditions for the preparation of CS are optimized for la

A Zn based metal organic framework as a heterogeneous catalyst for C-C bond formation reactions

Herein, we report the synthesis and application of a Zn-Bp-BTC MOF (Bp-4,4′-bipyridine; BTC-1,3,5-benzene tricarboxylic acid; MOF-metal organic framework) as a heterogeneous catalyst for mediating organic reactions. Initially, conditions were optimized for the Knoevenagel condensation reaction using Zn-Bp-BTC as a heterogeneous catalyst by varying the solvent, temperature and catalyst loading. Although the reaction proceeded at room temperature using methanol as the solvent, 60 °C offered the best yield in a shorter duration. Under optimized reaction conditions, a wide range of α,β-unsaturated dicyano compounds were prepared from the corresponding carbonyl precursor and malononitrile, the active methylene counterpart. Systematic investigation was also carried out to assess the role of the ligand and metal salt in the Knoevenagel condensation reaction. It was found that the Zn-Bp-BTC MOF catalyzed the reaction efficiently in comparison to its analogue Zn-BTC MOF and precursor Zn(NO3)2·6H2O. Finally, catalytic recycling and stability studies showed that the catalyst is able to mediate the reaction for up to five consecutive cycles without undergoing any significant chemical or morphological changes. Further, the catalyst was tested for its efficacy in a multi-component reaction (MCR). A MCR with the Zn-Bp-BTC MOF as the catalyst afforded good yields and there was no reaction in the absence of the catalyst. Similarly, the catalyst was tested for its efficiency in benzimidazole synthesis.

FIBROTIC TREATMENT

The present invention relates to a method for the treatment of fibrosis, in particular cardiac fibrosis, comprising the administration of an inhibitor of insulin-regulated aminopeptidase (IRAP). Preferable the IRAP inhibitor is chosen from the group inclu