1573010-32-8

Basic information

• Product Name: N⁽¹⁾-(4-hydroxy-2-oxo-2H-chromen-3-yl)-N⁽¹⁰⁾-phenyldecanediamide
• CAS NO: 1573010-32-8
• Molecular Weight: 436.508
• Mol File: 1573010-32-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N⁽¹⁾-(4-hydroxy-2-oxo-2H-chromen-3-yl)-N⁽¹⁰⁾-phenyldecanediamide(CAS DataBase Reference)
• NIST Chemistry Reference: N⁽¹⁾-(4-hydroxy-2-oxo-2H-chromen-3-yl)-N⁽¹⁰⁾-phenyldecanediamide(1573010-32-8)
• EPA Substance Registry System: N⁽¹⁾-(4-hydroxy-2-oxo-2H-chromen-3-yl)-N⁽¹⁰⁾-phenyldecanediamide(1573010-32-8)

Safety Data

• Hazardous Substances Data: 1573010-32-8(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 1573010-02-2 10-((4-hydroxy-2-oxo-2H-chromen-3-yl)amino)-10-oxodecanoic acid 
• 5725-79-1 3-amino-4-hydroxy-2H-chromen-2-one 
• 20261-31-8 4-hydroxy-3-nitrocoumarin 

Relevant articles and documents

Defining a minimum pharmacophore for simocyclinone D8 disruption of DNA gyrase binding to DNA

The increasing occurrence of drug-resistant bacterial infections in the clinic has created a need for new antibacterial agents. Natural products have historically been a rich source of both antibiotics and lead compounds for new antibacterial agents. The natural product simocyclinone D8 (SD8) has been reported to inhibit DNA gyrase, a validated antibacterial drug target, by a unique catalytic inhibition mechanism of action. In this work, we have used a deconstruction-reconstruction approach to prepare analogs of the coumarin subunit of SD8 and evaluated their ability to disrupt binding of the DNA gyrase enzyme to DNA in a surface plasmon resonance assay. This has led to a minimum pharmacophore required for disruption of binding. Springer Science+Business Media 2014.