157365-67-8

Basic information

• Product Name: 5-(uracil-5-ylmethylene)-3-phenyl-2-thiohydantoin
• CAS NO: 157365-67-8
• Molecular Weight: 314.324
• Mol File: 157365-67-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(uracil-5-ylmethylene)-3-phenyl-2-thiohydantoin(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(uracil-5-ylmethylene)-3-phenyl-2-thiohydantoin(157365-67-8)
• EPA Substance Registry System: 5-(uracil-5-ylmethylene)-3-phenyl-2-thiohydantoin(157365-67-8)

Safety Data

• Hazardous Substances Data: 157365-67-8(Hazardous Substances Data)

Upstream product

• 1195-08-0 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde 
• 2010-15-3 3-phenyl-2-thioxoimidazolidin-4-one 

Relevant articles and documents

Synthesis and Evaluation of Antiviral Activity of 2'-Deoxyuridines with 5-Methylene-2-thiohydantoin Substituents in the 5-Position

1-(2-Deoxy-3,5-bis-O-(4-methylbenzoyl)-D-erythro-pentofuranosyl)-5-formyluracil (4) was synthesized from 5-formyluracil and an appropriate methyl glycoside and condensed with 2-thiohydantoin (5a) and its corresponding 3-phenyl derivative 5b to give 5--2-thiohydantoins 7a and 7b, respectively, in 65-70percent yield.They were deprotected with sodium methoxide in methanol to give both anomers of the free nucleosides.In a different route 5-formyluracil (1) was condensed with 5b and subsequently with an appropriate methyl glycoside to give 7b. - Keywords: 2'-Deoxyuridines; 2-Thiohydantoins; Nucleoside synthesis; Antiviral activity.