157368-82-6

Basic information

• Product Name: 1,2-Benzisoxazol-3-amine,6-methoxy-(9CI)
• Synonyms: 1,2-Benzisoxazol-3-amine,6-methoxy-(9CI);6-Methoxybenzo[d]isoxazol-3-aMine;3-Amino-6-methoxy-1,2-benzisoxazole;6-Methoxy-benzo[d]isoxazol-3-ylamine
• CAS NO: 157368-82-6
• Molecular Formula: C₈H₈N₂O₂
• Molecular Weight: 164.16132
• Product Categories: OXAZOLE
• Mol File: 157368-82-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 348.9±22.0 °C(Predicted)
• Appearance: /
• Density: 1.304±0.06 g/cm3(Predicted)
• PKA: 2.92±0.30(Predicted)
• CAS DataBase Reference: 1,2-Benzisoxazol-3-amine,6-methoxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzisoxazol-3-amine,6-methoxy-(9CI)(157368-82-6)
• EPA Substance Registry System: 1,2-Benzisoxazol-3-amine,6-methoxy-(9CI)(157368-82-6)

Safety Data

• Hazardous Substances Data: 157368-82-6(Hazardous Substances Data)

Usage

General Description

1,2-Benzisoxazol-3-amine, 6-methoxy- (9CI) is a chemical compound that belongs to the benzisoxazole group. It is also known as 6-methoxy-1,2-benzisoxazol-3-amine and has a molecular formula of C8H8N2O2. 1,2-Benzisoxazol-3-amine,6-methoxy-(9CI) has a structure consisting of a benzene ring fused with an isoxazole ring, with a methoxy group attached to the 6th position. 1,2-Benzisoxazol-3-amine, 6-methoxy- (9CI) has been used in various research studies, particularly in the field of medicinal chemistry, as it displays potential biological activities and pharmacological properties. Furthermore, it has been investigated for its potential role as a therapeutic agent in the treatment of various diseases and conditions.

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Relevant articles and documents

AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF A7-NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel aminobenzisoxazole compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of ot7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

Preparation of 2-hydroxybenzamidines from 3-aminobenzisoxazoles

2-Hydroxybenzamidines have been prepared from 3-aminobenzisoxazoles by reductive cleavage of the nitrogen-oxygen bond using catalytic hydrogenation, Zn/AcOH or NiCl2/NaBH4. This ring-opening reaction can be accomplished chemoselectively in the presence of a variety of hydrogenation-sensitive functional groups including an aryl bromide, benzyl carbamate, and olefin.

Use of the Kaiser Oxime Resin in the Solid-Phase Synthesis of 3-Aminobenzisoxazoles

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