157371-07-8

Basic information

• Product Name: 4-Pyridinemethanol,alpha-ethyl-,(alphaS)-(9CI)
• Synonyms: 4-Pyridinemethanol,alpha-ethyl-,(alphaS)-(9CI)
• CAS NO: 157371-07-8
• Molecular Formula: C8H11NO
• Molecular Weight: 137.18
• Product Categories: PYRIDINE
• Mol File: 157371-07-8.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Pyridinemethanol,alpha-ethyl-,(alphaS)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinemethanol,alpha-ethyl-,(alphaS)-(9CI)(157371-07-8)
• EPA Substance Registry System: 4-Pyridinemethanol,alpha-ethyl-,(alphaS)-(9CI)(157371-07-8)

Safety Data

• Hazardous Substances Data: 157371-07-8(Hazardous Substances Data)

Upstream product

• 872-85-5 pyridine-4-carbaldehyde 
• 10467-10-4 ethylmagnesium iodide 
• 62369-32-8 4-(ethoxymethyl)pyridine 
• 925-90-6 ethylmagnesium bromide 
• 1122-81-2 4-n-propylpyridine 
• 91-17-8 decalin 
• 71-43-2 benzene 
• 1822-51-1 4-picolylchloride hydrochloride 
• 557-20-0 diethylzinc 
• 1701-69-5 1-(4-pyridyl)-1-propanone 

Downstream Products

• 1701-69-5 1-(4-pyridyl)-1-propanone 
• 17944-59-1 3-(pyridin-4-yl)propyl chloride hydrochloride 
• 1352067-90-3 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-(pyridin-4-yl)propyl)piperidin-3-yl)acetic acid 

Relevant articles and documents

2,2′-Bipyridine-α,α′-trifluoromethyl-diol ligand: Synthesis and application in the asymmetric Et2Zn alkylation of aldehydes

A chiral 2,2′-bipyridine ligand (1) bearing α,α′-trifluoromethyl-alcohols at 6,6′-positions was designed in five steps affording either the R,R or S,S enantiomer with excellent stereoselectivities, i.e. 97% de, >99% ee and >99.5% de, >99.5% ee, respectively. The key step for reaching high levels of stereoselectivity was demonstrated to be the resolution of the α-CF3-alcohol using (S)-ibuprofen as the resolving agent. An initial application for the 2,2′-bipyridine-α,α′-CF3-diol ligand was highlighted in the ZnII-catalyzed asymmetric ethylation reaction of aromatic, heteroaromatic, and aliphatic aldehydes. Synergistic electron deficiency and steric hindrance properties of the newly developed ligand afforded the corresponding alcohols in good to excellent yields (up to 99%) and enantioselectivities (up to 95% ee). As observed from single crystal diffraction analysis, the complexation of the 2,2′-bipyridine-α,α′-CF3-diol ligand generates an unusual hexacoordinated ZnII.

Chiral 2-(2-hydroxyaryl)alcohols (HAROLs) with a 1,4-diol scaffold as a new family of ligands and organocatalysts

Efficient and modular syntheses of chiral 2-(2-hydroxyaryl)alcohols (HAROLs), novel 1,4-diols carrying one phenolic and one alcohol hydroxyl group, have been developed which led to generation of a small library of structurally diverse HAROLs in enantiomerically pure form. Of the different HAROLs examined, a HAROL based on the indan backbone exhibited the highest activity and enantioselectivity in the 1,2-addition of certain organometallic compounds to aldehydes in the presence of Ti(OiPr)4 (up to 97% y, 88% ee) and performed as a hydrogen-bond donor organocatalyst in the Morita-Baylis-Hillman reaction, promoted by trialkylphosphines.

NEW COMPOUNDS AND USES THEREOF FOR DETECTION OF TARGET MOLECULES IN A SAMPLE

The present invention relates to new profluorophores and conjugates thereof and their use for the detection of target molecule in a sample, in particular nucleic acid target molecules. The invention relates to new profluorophores and new fluorophores and methods of use thereof particularly useful in the fields of diagnostics and quality control.