1574401-91-4Relevant articles and documents
A scalable and regioselective synthesis of 2-difluoromethyl pyridines from commodity chemicals
Desrosiers, Jean-Nicolas,Kelly, Christopher B.,Fandrick, Daniel R.,Nummy, Larry,Campbell, Scot J.,Wei, Xudong,Sarvestani, Max,Lee, Heewon,Sienkiewicz, Alexander,Sanyal, Sanjit,Zeng, Xingzhong,Grinberg, Nelu,Ma, Shengli,Song, Jinhua J.,Senanayake, Chris H.
supporting information, p. 1724 - 1727 (2014/04/17)
A scalable de novo synthesis of difluoromethyl pyridines from inexpensive materials is reported. The pyridyl subunit is built around the difluoromethyl group rather than a late stage introduction of this moiety. This user-friendly approach allows access to a diverse range of substitution patterns on all positions on the ring system and on the difluoromethyl group.
