157459-53-5

Basic information

• Product Name: 3,4-dimethoxy-6-cyanoaniline-1-yl formamide
• Synonyms: 3,4-dimethoxy-6-cyanoaniline-1-yl formamide
• CAS NO: 157459-53-5
• Molecular Weight: 221.216
• Mol File: 157459-53-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,4-dimethoxy-6-cyanoaniline-1-yl formamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dimethoxy-6-cyanoaniline-1-yl formamide(157459-53-5)
• EPA Substance Registry System: 3,4-dimethoxy-6-cyanoaniline-1-yl formamide(157459-53-5)

Safety Data

• Hazardous Substances Data: 157459-53-5(Hazardous Substances Data)

Upstream product

• 26961-27-3 2-amino-4,5-dimethoxybenzonitrile 
• 917-61-3 sodium isocyanate 

Downstream Products

• 23680-84-4 2-chloro-6,7-dimethoxyquinazolin-4-amine 

Relevant articles and documents

A NOVEL PROCESS FOR THE PREPARATION OF 2-HALO-4-AMINOQUINAZOLINES

2-Halo-4-aminoquinazolines are produced by a one-step process involving intramolecular cyclization of appropriately substituted formamide derivatives in the presence of phosphorous oxyhalides. Exemplary of the process is the intramolecular cyclization of 3,4-dimethoxy-6-cyanoaniline-1-yl formamide in the presence of phosphorous oxychloride to 2-chloro-4-amino-6,7-dimethoxyquinazoline. These chemical compounds are utilized as intermediates in the preparation of some of the important antihypertensive agents e.g. 2-chloro-4-amino-6,7-dimethoxyquinazolines is used for the synthesis of alfuzosin hydrochloride.