1575-38-8Relevant articles and documents
-
Scott,Tomlinson
, p. 417,419 (1959)
-
NOVEL SUBSTITUTED BICYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS
-
Paragraph 0275; 0276, (2016/06/13)
The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
A novel benzimidazole derivative binds to the DNA minor groove and induces apoptosis in leukemic cells
Hegde, Mahesh,Sharath Kumar, Kothanahally S.,Thomas, Elizabeth,Ananda, Hanumappa,Raghavan, Sathees C.,Rangappa, Kanchugarakoppal S.
, p. 93194 - 93208 (2015/11/17)
DNA minor groove binders are an important class of chemotherapeutic agents. These small molecule inhibitors interfere with various cellular processes like DNA replication and transcription. Several benzimidazole derivatives showed affinity towards the DNA