1575700-07-0Relevant articles and documents
Regio-Divergent C—H Alkynylation with Janus Directing Strategy via Ir(III) Catalysis
Li, Xianwei,Liang, Guangxin,Shi, Zhang-Jie
supporting information, p. 929 - 934 (2020/06/02)
Directing strategy has been extensively exploited to maintain activity and selectivity for the rapid access to functionalized molecules and pharmaceutical targets. However, ‘one-to-one’ activation model was usually achieved through traditional directing strategy. Herein, we achieved ‘one-to-two’ activation model by slight modification of simple and practical ketoxime and amide functionality. With judicious choice of directing groups, Csp3—H and Csp2—H bond alkynylation reaction, and more significantly, dehydrogenative Csp3—H alkynylation, were realized, enabling the regio-divergent late-stage modifications of pharmaceuticals.
B(C6F5)3-catalyzed hydrogenation of oxime ethers without cleavage of the N-O bond
Mohr, Jens,Oestreich, Martin
supporting information, p. 13278 - 13281 (2015/01/16)
The hydrogenation of oximes and oxime ethers is usually hampered by N-O bond cleavage, hence affording amines rather than hydroxylamines. The boron Lewis acid B(C6F5)3 is found to catalyze the chemoselective hydrogenation
