15761-96-3 Usage
Description
2-Benzyl-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide, commonly referred to as TBO, is a phosphorinane compound characterized by its fluorescent properties. It is recognized for its unique ability to selectively stain amyloid deposits in tissue samples, which is particularly valuable in the study of Alzheimer's disease and other neurodegenerative conditions. TBO's stability and non-toxic nature make it a versatile compound for various applications in research and medical diagnostics.
Uses
Used in Neurodegenerative Disease Research:
TBO is utilized as a fluorescent dye for selectively staining amyloid deposits in tissue samples. This application is crucial for the study of Alzheimer's disease and other neurodegenerative conditions, aiding researchers in visualizing and analyzing the presence and distribution of amyloid plaques, which are a hallmark of these diseases.
Used in Optical Sensors Development:
In the field of sensor technology, TBO is employed in the development of optical sensors. Its fluorescent properties allow for the sensitive detection of specific molecules or conditions, making it a valuable component in creating advanced sensor systems for various analytical and diagnostic purposes.
Used in Fluorescence Microscopy:
TBO is also used in fluorescence microscopy as a staining agent. Its ability to produce a strong fluorescent signal upon binding to specific targets makes it an effective tool for imaging cellular and molecular structures, enhancing the visualization of biological samples and contributing to a deeper understanding of biological processes.
Used in Pharmaceutical Research:
Although not explicitly mentioned in the provided materials, TBO's properties may also make it a candidate for use in pharmaceutical research, particularly in the development of drugs targeting amyloid-related diseases. Its selectivity for amyloid deposits could potentially be leveraged in the design of drugs that aim to modulate or clear these structures, offering new therapeutic strategies for treating neurodegenerative conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 15761-96-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,7,6 and 1 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 15761-96:
(7*1)+(6*5)+(5*7)+(4*6)+(3*1)+(2*9)+(1*6)=123
123 % 10 = 3
So 15761-96-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H17O3P/c1-12(2)9-14-16(13,15-10-12)8-11-6-4-3-5-7-11/h3-7H,8-10H2,1-2H3
15761-96-3Relevant articles and documents
Studies on the efficient generation of phosphorus-carbon bonds via a rearrangement of PIII esters catalysed by trimethylhalosilanes
Dabkowski, Wojciech,Ozarek, Alfred,Olejniczak, Sebastian,Cypryk, Marek,Chojnowski, Julian,Michalski, Jan
experimental part, p. 1747 - 1756 (2009/09/25)
Halotrimethylsilanes Me3SiX (X = Br, I) catalyse rearrangements of tricoordinate phosphorus esters R′R″P-OR into the corresponding phosphoryl systems R′R″P(O)R. This provides a simple and efficient route to a variety of structures containing phosphorus-carbon bonds, under mild conditions and with good yields. The reaction mechanism was investigated in detail by 31P NMR spectroscopy and independent synthesis of the reaction intermediates. It has been demonstrated that the primary products of this catalytic reaction are halogeno PIII structures R′R″PX and silyl ethers ROSiMe3 and that they subsequently react to give the corresponding phosphorus silyl esters - Me 3SiOPR′R″-and alkyl halides RX. At higher temperatures these intermediates then react to form R′R″P(P)R compounds. This paper also features the surprising observation that when esters Ph 2POR and halotrimethylsilanes Me3SiX (X = Br, I) are used in 2:1 ratio, phosphonium salts Ph2R2P+X - and trimethylsilyl diphenylphosphinate - Ph2P(O) OSiMe3 - are formed as the major products. Experimental evidence indicates that the mechanisms of both reactions are fundamentally different from that of the Michaelis-Arbuzov reaction. Me3SiCl is not reactive and this paper explains why.
