157650-20-9

Basic information

• Product Name: 2-(3,4-bis(pivaloyloxy)phenyl)-5-hydroxy-4-oxo-4H-chromene-3,7-diyl bis(2,2-dimethylpropanoate)
• Synonyms: 2-(3,4-bis(pivaloyloxy)phenyl)-5-hydroxy-4-oxo-4H-chromene-3,7-diyl bis(2,2-dimethylpropanoate)
• CAS NO: 157650-20-9
• Molecular Weight: 638.712
• Mol File: 157650-20-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(3,4-bis(pivaloyloxy)phenyl)-5-hydroxy-4-oxo-4H-chromene-3,7-diyl bis(2,2-dimethylpropanoate)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-bis(pivaloyloxy)phenyl)-5-hydroxy-4-oxo-4H-chromene-3,7-diyl bis(2,2-dimethylpropanoate)(157650-20-9)
• EPA Substance Registry System: 2-(3,4-bis(pivaloyloxy)phenyl)-5-hydroxy-4-oxo-4H-chromene-3,7-diyl bis(2,2-dimethylpropanoate)(157650-20-9)

Safety Data

• Hazardous Substances Data: 157650-20-9(Hazardous Substances Data)

Upstream product

• 117-39-5 quercetol 
• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 529-51-1 5-O-methylquercetin 
• 157650-21-0 5-O-Methyl-3,3',4',7-Tetrapivaloyl-Quercetin 

Relevant articles and documents

Simple synthesis of azaleatine from quercetin

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Regioselective O-derivatization of quercetin via ester intermediates. An improved synthesis of rhamnetin and development of a new mitochondriotropic derivative

The regioselective synthesis of several quercetin (3,3',4',5,7-pentahydroxy flavone) tetraesters bearing a single free OH on 5-C was achieved in good yield by proper choice of reaction conditions using common esterification procedures. Tetracetylated quercetin with the free OH on 7-C was selectively obtained instead via imidazole-promoted deacylation of the corresponding pentaester. Unambiguous structural characterization of the two isomeric tetraacetyl quercetin derivatives was obtained by combined HSQC and HMBC 2D-NMR analysis. These molecules can be used as starting materials for the regioselective synthesis of other derivatives. High yield syntheses of the natural polyphenol rhamnetin (7-O-methylquercetin) and of the new mitochondriotropic compound 7-(4-triphenylphosphoniumbutyl) quercetin iodide are reported as examples.