15769-84-3Relevant articles and documents
Cobalt-Catalyzed ortho-C?H Functionalization/Alkyne Annulation of Benzylamine Derivatives: Access to Dihydroisoquinolines
Martínez, ángel Manu,Rodríguez, Nuria,Gómez-Arrayás, Ramón,Carretero, Juan C.
supporting information, p. 11669 - 11676 (2017/08/30)
A practical picolinamide-directed C?H functionalization/alkyne annulation of benzylamine derivatives enabling access to the previously elusive 1,4-dihydroisoquinoline skeleton was developed using molecular O2 as the sole oxidant and Co(OAc)2 as precatalyst. The method is compatible with both internal and terminal alkynes and shows high versatility and functional-group tolerance. Furthermore, full preservation of enantiopurity is observed when using non-racemic α-substituted benzylamine derivatives. Kinetic analysis of the reagents and catalyst, labeling experiments, and the isolation and identification of catalytically competent Co-complexes revealed important insights about the mechanism.
A simple preparation of amides from acids and amines by heating of their mixture
Jursic,Zdravkovski
, p. 2761 - 2770 (2007/10/02)
Heating a mixture of an amine and an acid is demonstrated as the method of choice for the preparation of many amides. The yields depend on the physical properties and thermal stability of the reactants and range from good to excellent. The ideal reactants
