157736-54-4

Basic information

• Product Name: α-<<4-methylphenylsulfonyl>oxy>methyl-α-methylbenzenacetonitrile
• Synonyms: α-<<4-methylphenylsulfonyl>oxy>methyl-α-methylbenzenacetonitrile
• CAS NO: 157736-54-4
• Molecular Weight: 315.393
• Mol File: 157736-54-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: α-<<4-methylphenylsulfonyl>oxy>methyl-α-methylbenzenacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: α-<<4-methylphenylsulfonyl>oxy>methyl-α-methylbenzenacetonitrile(157736-54-4)
• EPA Substance Registry System: α-<<4-methylphenylsulfonyl>oxy>methyl-α-methylbenzenacetonitrile(157736-54-4)

Safety Data

• Hazardous Substances Data: 157736-54-4(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 27746-76-5 α-hydroxymethyl-α-methylbenzenacetonitrile 
• 1823-91-2 1-phenylethyl cyanide 

Downstream Products

• 5961-33-1 3-methyl-3-phenylazetidine 
• 98-83-9 isopropenylbenzene 

Relevant articles and documents

A NOVEL SYNTHESIS OF 3,3-(SPIRO)SUBSTITUTED AZETIDINES

A smooth and efficient new synthesis for 3,3-disubstituted azetidines, starting from readily available nitriles, was estabilished: α-hydroxymethylation of the starting materials, followed by O-tosylation and LiAlH4-reduction of the key intermediates thus obtained, led - via spontaneous cyclization of the intermediate amino derivatives - to 3,3-disubstituted azetidines.Scope and limitations of this new method were studied with respect to generalized applicability: the target compounds were accessible in good yields for a variety of starting materials (cyclic and acyclic di(hetero)aryl, (hetero)arylalkyl, dialkyl, as well as basic moieties).The products thus obtained may be of interest for ensuing conversions due to their unblocked nitrogen.