157759-50-7

Basic information

• Product Name: Bromo-PEG1-CH2CO2tBu
• Synonyms: Bromo-PEG1-CH2CO2tBu;Bromo-PEG1-CH2COOtBu;tert-Butyl 2-(2-bromoethoxy)acetate;t-butyl acetate-PEG1-bromide
• CAS NO: 157759-50-7
• Molecular Formula: C8H15BrO3
• Molecular Weight: 239.1069
• Mol File: 157759-50-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 268.1±15.0 °C(Predicted)
• Appearance: /
• Density: 1.301±0.06 g/cm3(Predicted)
• Solubility: Soluble in DCM
• CAS DataBase Reference: Bromo-PEG1-CH2CO2tBu(CAS DataBase Reference)
• NIST Chemistry Reference: Bromo-PEG1-CH2CO2tBu(157759-50-7)
• EPA Substance Registry System: Bromo-PEG1-CH2CO2tBu(157759-50-7)

Safety Data

• Hazardous Substances Data: 157759-50-7(Hazardous Substances Data)

Usage

Description

Bromo-PEG1-CH2CO2tBu is a PEG (polyethylene glycol) linker that features a bromide group and a t-butyl protected carboxyl group. This molecule is designed to enhance solubility in aqueous environments due to the hydrophilic nature of the PEG spacer. The presence of the bromide group makes it an excellent candidate for nucleophilic substitution reactions, while the t-butyl protected carboxyl group can be selectively deprotected under acidic conditions, allowing for further functionalization and reaction with other molecules.

Uses

Used in Bioconjugation and Drug Synthesis:
Bromo-PEG1-CH2CO2tBu is used as a bioconjugation agent for the attachment of various molecules, such as drugs, peptides, or other biomolecules, to PEG chains. The bromide group facilitates the coupling process through nucleophilic substitution, while the PEG spacer improves the solubility and stability of the resulting conjugate in aqueous media.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Bromo-PEG1-CH2CO2tBu is used as a component in the design of drug delivery systems. The PEG linker can be used to attach drugs to nanoparticles or other carriers, improving their solubility, circulation time, and bioavailability. The t-butyl protected carboxyl group allows for controlled release of the drug under specific conditions, such as in response to a change in pH or the presence of specific enzymes.
Used in Chemical Synthesis:
Bromo-PEG1-CH2CO2tBu can be utilized as an intermediate in the synthesis of more complex molecules, taking advantage of the reactivity of the bromide group and the protective nature of the t-butyl group. This allows for the stepwise construction of molecules with specific functionalities, which can be further modified or used in various applications.
Used in Material Science:
In the field of material science, Bromo-PEG1-CH2CO2tBu can be employed as a building block for the development of novel materials with tailored properties. The PEG linker can be used to create hydrophilic polymers or copolymers, while the bromide and t-butyl protected carboxyl groups provide opportunities for crosslinking or further functionalization, leading to materials with improved properties for specific applications.