15782-66-8

Basic information

• Product Name: 1-ADAMANTANEACETIC ACID ETHYL ESTER
• Synonyms: ETHYL 1-ADAMANTYLACETATE;ETHYL 2-(1-ADAMANTYL)ACETATE;ETHYL ADAMANTANE-1-ACETATE;1-ADAMANTANEACETIC ACID ETHYL ESTER;1-ADAMANTYLACETIC ACID ETHYL ESTER;AKOS BC-0504;tricyclo[3.3.1.1~3,7~]decane-1-acetic acid, ethyl ester;Ethyl 1-adamantaneacetate
• CAS NO: 15782-66-8
• Molecular Formula: C₁₄H₂₂O₂
• Molecular Weight: 222.32
• Product Categories: Adamantane derivatives
• Mol File: 15782-66-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 80.5-82℃ (ethanol, 75% )
• Boiling Point: 277.1±8.0℃ (760 Torr)
• Flash Point: 116.0±9.7℃
• Appearance: /
• Density: 1.067±0.06 g/cm3 (20 ºC 760 Torr)
• CAS DataBase Reference: 1-ADAMANTANEACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ADAMANTANEACETIC ACID ETHYL ESTER(15782-66-8)
• EPA Substance Registry System: 1-ADAMANTANEACETIC ACID ETHYL ESTER(15782-66-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 15782-66-8(Hazardous Substances Data)

Usage

General Description

1-Adamantaneacetic acid ethyl ester, also known as ethyl 1-adamantaneacetic acid, is a synthetic chemical compound used in research and laboratory settings. It is a ester derivative of adamantaneacetic acid, a carboxylic acid compound. This chemical is often utilized as a precursor in the synthesis of other pharmaceutical and organic compounds due to its unique molecular structure and properties. It is also used in the production of various dyes, pigments, and coatings. 1-Adamantaneacetic acid ethyl ester is considered to be a moderately hazardous substance and should be handled and stored with care in accordance with proper safety protocols and guidelines.

InChI:InChI=1S/C14H22O2/c1-2-16-13(15)9-14-6-10-3-11(7-14)5-12(4-10)8-14/h10-12H,2-9H2,1H3

Upstream product

• 64-17-5 ethanol 
• 144499-21-8 Trifluoro-acetic acid 2-adamantan-1-yl-1-cyano-1-(pyridin-2-ylsulfanyl)-ethyl ester 
• 19835-38-2 1-adamantylacetyl chloride 
• 925-90-6 ethylmagnesium bromide 
• 768-90-1 1-Adamantyl bromide 
• 105-36-2 ethyl bromoacetate 
• 91233-19-1 1-(adamantane-1-carbonyloxy)pyridine-2(1H)-thione 
• 4942-47-6 (adamant-1-yl)-acetic acid 
• 31897-93-5 N-methyl-1-adamantaneacetamide 

Downstream Products

• 1313008-01-3 2-adamantyl-3-(2,3-dimethoxyphenyl)propan-1-ol 
• 1313008-04-6 2-adamantyl-3-(2,3-dimethoxyphenyl)propyl methanesulfonate 
• 1313008-09-1 3-adamantyl-4-(2,3-dimethoxyphenyl)butanenitrile 
• 1313008-15-9 3-adamantyl-4-(2,3-dimethoxyphenyl)butanoic acid 
• 1313007-98-5 ethyl 2-adamantyl-3-(2,3-dimethoxyphenyl)-3-hydroxypropanoate 
• 4942-47-6 (adamant-1-yl)-acetic acid 
• 19026-80-3 2-[4-(tricyclo[3.3.1.1^3,7]dec-1-yl)phenyl]acetohydrazide 

Relevant articles and documents

Cobalt-Catalyzed Esterification of Amides

The first cobalt-catalyzed amide activation of N-Boc-amides, and their conversion into esters, is reported here. This new methodology presents a very practical process that does not require an inert atmosphere, uses an inexpensive cobalt catalyst, and proceeds under mild reaction conditions. This catalytic system has a broad substrate scope and has been shown to be highly efficient, with catalyst loadings as low as 1 mol %.

The Invention of Radical Reactions. XXXIII Homologation Reactions of Carboxylic Acids by Radical Chain Chemistry

Various carbon radicals can be generated from carboxylic acids via the corresponding Barton esters.These radicals can be used for the synthesis of longer chain homologues of the original acids.

Chain-elongation and Degradation of Carboxylic Acids by Barton-ester Based Radical Chemistry

The reaction of α-trifluoroacetoxy acrylates and acrylonitriles with carbon radicals formed from carboxylic acids gives adducts that can be transformed into vic-diols, esters, amides, and homoaldehydes in good to high yield.Aldoses can be smoothly degraded to the corresponding nor- or bis-nor compounds using radical chemistry.