1578245-95-0

Basic information

• Product Name: 8-chloro-2-(methylsulfanyl)pyrido[3,4-d]pyrimidine
• Synonyms: 8-chloro-2-(methylsulfanyl)pyrido[3,4-d]pyrimidine
• CAS NO: 1578245-95-0
• Molecular Weight: 211.675
• Mol File: 1578245-95-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 8-chloro-2-(methylsulfanyl)pyrido[3,4-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-chloro-2-(methylsulfanyl)pyrido[3,4-d]pyrimidine(1578245-95-0)
• EPA Substance Registry System: 8-chloro-2-(methylsulfanyl)pyrido[3,4-d]pyrimidine(1578245-95-0)

Safety Data

• Hazardous Substances Data: 1578245-95-0(Hazardous Substances Data)

Upstream product

• 1578245-94-9 2-(methylsulfanyl)-7H,8H-pyrido[3,4-d]pyrimidin-8-one 
• 1578245-93-8 methyl 5-[(E)-2-ethoxyethenyl]-2-(methylsulfanyl)pyrimidine-4-carboxylate 
• 50593-91-4 methyl 5-bromo-2-(methylsulfanyl)pyrimidine-4-carboxylate 
• 50593-92-5 5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid 

Downstream Products

• 1578244-15-1 N⁸-cyclopropylmethyl-N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine 
• 1578244-16-2 N₈-cyclopentyl-N₂-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N₈-methylpyrido[3,4-d]pyrimidine-2,8-diamine 
• 1578244-17-3 N₈-isopentyl-N₂-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine 
• 1578244-20-8 8-(3,3-difluoroazetidin-1-yl)-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine 
• 1578244-21-9 N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-8-(2-methylpyrrolidin-1-yl)pyrido[3,4-d]pyrimidin-2-amine 
• 1578244-23-1 N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-8-(6-azaspiro[3.4]octan-6-yl)pyrido[3,4-d]pyrimidin-2-amine 
• 1578244-24-2 N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-8-(3-methoxyazetidin-1-yl)pyrido[3,4-d]pyrimidin-2-amine 
• 1578244-26-4 N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N⁸-(tetrahydro-2H-pyran-4-yl)pyrido[3,4-d]pyrimidine-2,8-diamine 
• 1578244-27-5 N⁸-cyclohexylmethyl-N²-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine 
• 1578244-30-0 N₈-(3,3-dimethylbutan-2-yl)-N₂-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine 
• 1578244-36-6 N₂-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N₈-(tetrahydrofuran-3-yl)pyrido[3,4-d]pyrimidine-2,8-diamine 
• 1578244-38-8 N₂-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N₈-((tetrahydrofuran-3-yl)methyl)pyrido[3,4-d]pyrimidine-2,8-diamine 
• 1578244-39-9 1-(2-((2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyrrolidin-3-ol 
• 1578244-41-3 N₂-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N₈-methyl-N₈-(tetrahydro-2H-pyran-4-yl)pyrido[3,4-d]pyrimidine-2,8-diamine 

Relevant articles and documents

SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE

The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, immunodermatologic disorders such as palmoplantar pustulosis and hidradenitis suppurativa, and metabolic disorders such as obesity and diabetes.

INHIBITOR COMPOUNDS

The present invention relates to compounds of formula (I), wherein R, R, Ar, W, X and Z are all as defined herein. The compounds of the present invention are known to inhibit the spindle checkpoint function of Monospindle 1 (Mps1 - also known as TTK) kinases either directly or indirectly via interaction with the Mps1 kinase itself. In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them