15785-52-1

Basic information

• Product Name: Cyclopropylalanine
• Synonyms: Cyclopropylalanine;(+/-)-alpha-Aminocyclopropanepropanoic acid;3-Cyclopropylalanine;alhpa-Aminocyclopropanepropanoic acid;Cyclopropanealanine;DL-alpha-Aminocyclopropanepropionic acid;2-aMino-3-cyclopropylpropanoic acid;DL-3-cyclopropylalanine
• CAS NO: 15785-52-1
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.157
• Mol File: 15785-52-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 258℃
• Flash Point: 110℃
• Appearance: /
• Density: 1.218
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.32±0.10(Predicted)
• CAS DataBase Reference: Cyclopropylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropylalanine(15785-52-1)
• EPA Substance Registry System: Cyclopropylalanine(15785-52-1)

Safety Data

• Hazardous Substances Data: 15785-52-1(Hazardous Substances Data)

Usage

General Description

Cyclopropylalanine is a non-natural amino acid that is typically used in scientific research and developmental studies, targeting certain enzymes and proteins. It is similar to alanine, a naturally occurring amino acid, but has a cyclopropyl ring in place of the methyl group. The incorporation of cyclopropylalanine into peptides can alter their biological activity. Researchers use this chemical to study and manipulate protein function and structure or to create new pharmaceutical drugs. It requires proper handling and usage due to its potential effects on the body.

InChI:InChI=1S/C6H11NO2/c7-5(6(8)9)3-4-1-2-4/h4-5H,1-3,7H2,(H,8,9)

Upstream product

• 18941-95-2 cyclopropylmethyl-formylamino-malonic acid diethyl ester 
• 133992-69-5 N-acetyl-3-cyclopropylalanine 
• 33574-02-6 cyclopropylmethyl iodide 
• 170115-96-5 2-amino-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylacetamide 
• 170642-22-5 (R)-2-Amino-3-cyclopropyl-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-propionamide 
• 1198408-99-9 (1S)-1-methyl-2-oxo-2-tetrahydro-1H-pyrrolylethyl 2-bromo-3-cyclopropylpropanoate 
• 1198409-01-6 (1S)-1-methyl-2-oxo-2-tetrahydro-1H-pyrrolylethyl N-(p-methoxyphenyl)-2-amino-3-cyclopropylpropanoate 
• 102693-69-6 (S)-2-Benzyloxycarbonylamino-3-cyclopropyl-propionic acid benzyl ester 
• 113741-17-6 (S)-2-amino-3-cyclopropylpropionic acid benzyl ester 
• 849340-24-5 2-tert-butoxycarbonylamino-3-cyclopropylacrylic acid benzyl ester 
• 406681-37-6 (2S)-2-tert-butoxycarbonylamino-3-cyclopropyl-propionic acid benzyl ester 
• 200482-55-9 4-cyclopropylmethylene-2-phenyl-4H-oxazol-5-one 
• 1027976-19-7 cyclopropylacetamidomalonic acid 
• 174543-84-1 diethyl cyclopropylacetamidomalonate 

Downstream Products

• 177913-96-1 (S)-3-Cyclopropyl-2-[((2S,6R)-2,6-dimethyl-piperidine-1-carbonyl)-amino]-propionic acid benzyl ester 
• 300853-97-8 2-(S)-hydroxy-3-(cyclopropyl)propanoic acid 
• 457059-27-7 (S)-3-cyclopropylalanine tert-butyl ester 
• 89483-06-7 (2S)-2-[[(tert-butoxy)carbonyl]amino]-3-cyclopropylpropanoic acid 
• 89483-08-9 (R)-2-((tert-butoxycarbonyl)amino)-3-cyclopropylpropanoic acid 
• 1629857-65-3 C₁₄H₁₅NO₂ 
• 732231-41-3 methyl (S)-2-amino-3-cyclopropylpropanoate 
• 104347-84-4 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-cyclopropylpropanoate 

Relevant articles and documents

METHOD OF PRODUCING OPTICALLY ACTIVE AMINO ACID DERIVATIVE

The present application relates to a method for producing an optically active α-amino acid derivative, comprising steps of reacting an α-haloester derivative represented by the general formula (1): of which alcohol part of the ester group is an optically active alcohol derivative, with an amine compound; then deprotecting the obtained compound; further carrying out an ester exchange reaction. According to the present invention method, it is possible to easily produce an optically active α-amino acid ester derivative which is useful as an intermediate for drugs with high selectivity.

Phosphinoferrocenylaminophosphines as novel and practical ligands for asymmetric catalysis

(Matrix Presented) A new series of ligands with a novel phosphine-aminophosphine ligation design as depicted in structure 1 has been prepared on a ferrocenylethyl backbone. These BoPhoz ligands of structure 2 have afforded exceedingly high activity and enantioselectivity in the rhodium-catalyzed asymmetric hydrogenation of dehydro-α-amino acid derivatives, itaconic acids, and α-ketoesters. These air-stable ligands are readily prepared from cost-effective and non-pyrophoric intermediates.

A convenient synthesis of (L)-β-cyclopropylalanine

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