15789-03-4Relevant articles and documents
METHODS OF MAKING HIGH ENANTIOSELECTIVE SECONDARY ALCOHOLS
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Paragraph 0074; 0075, (2020/09/08)
A new process to synthesis of compound OBI-3424 R-form and S-form products is provided. The "R-form" compound OBI-3423 was first synthesized with 48% overall yield from compound OBI-3424-5 by installation of the labile phosphate motif at later stage. The stereo chemistry is established by 5 steps chemo-enzyme combination synthesis to afford 99% optical purity, After then, the "S-form" compound OBI-3424 is prepared with improving overall yield of 54% from compound OBI-3424-5. The stereo chemistry is established by 4 steps combination of chemo-enzyme synthesis with excellent optical purity of 99%.
Camptothecin derivative with antitumor activity, and preparation method and application thereof
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Paragraph 0105; 0107; 0111; 0113; 0118; 0120; 0124; 0126, (2019/11/04)
The present invention relates to a camptothecin derivative with antitumor activity, and a preparation method and an application thereof. The camptothecin derivative is a compound having a structure represented by general formula (I), or a pharmaceutically acceptable salt, an enantiomer, a diastereomer, a tautomer, a solvate, a polymorph or a prodrug thereof. The camptothecin derivative has a goodantitumor cell proliferation activity, has an inhibitory activity against specific tumor cells at a very low concentration, and has excellent selectivity; and the side effects of the camptothecin derivative represented by the general formula (I) are greatly less than those of Tripterygium wilfordii Hook. f., so the camptothecin derivative can be used to treat specific tumors.
Bifunctional organocatalysts for the asymmetric synthesis of axially chiral benzamides
Miyaji, Ryota,Wada, Yuuki,Matsumoto, Akira,Asano, Keisuke,Matsubara, Seijiro
supporting information, p. 1518 - 1523 (2017/08/14)
Bifunctional organocatalysts bearing amino and urea functional groups in a chiral molecular skeleton were applied to the enantioselective synthesis of axially chiral benzamides via aromatic electrophilic bromination. The results demonstrate the versatilit