1579-14-2

Basic information

• Product Name: 1H-Inden-1-one, 2-chloro-2,3-dihydro-
• Synonyms: 1H-Inden-1-one, 2-chloro-2,3-dihydro-
• CAS NO: 1579-14-2
• Molecular Formula: C₉H₇ClO
• Molecular Weight: 166.6
• Mol File: 1579-14-2.mol
• Article Data: 18

Chemical Properties

• Melting Point: 38-39 °C
• Boiling Point: 278.0±29.0 °C(Predicted)
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 1H-Inden-1-one, 2-chloro-2,3-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Inden-1-one, 2-chloro-2,3-dihydro-(1579-14-2)
• EPA Substance Registry System: 1H-Inden-1-one, 2-chloro-2,3-dihydro-(1579-14-2)

Safety Data

• Hazardous Substances Data: 1579-14-2(Hazardous Substances Data)

Usage

Physical state

White or light yellow crystalline solid

Uses

Building block in the synthesis of various organic compounds, production of pharmaceuticals, agrochemicals, and other specialty chemicals

Importance

Useful intermediate in the manufacturing of various aromatic and heterocyclic compounds, potential as a reactive intermediate in organic synthesis, and has several applications in the chemical industry.

Upstream product

• 67864-28-2 2-chloroindan-1-ol 
• 83-33-0 inden-1-one 
• 17215-77-9 2,2-dichloro-2,3-dihydro-1H-inden-1-one 
• 31928-64-0 1-trimethylsilyloxy-3H-indene 
• 73951-59-4 trans-2-chloro-indan-1-ol 
• 185436-23-1 (-)-(1S,2R)-2-chloro-2,3-dihydro-1H-inden-1-ol 
• 107-21-1 ethylene glycol 

Downstream Products

• 404-24-0 2,2,2-trifluoro-N-phenylacetamide 
• 139517-16-1 10b-hydroxy-5,5a,6,9-tetrahydroindeno<2,1-b>indole 
• 79892-22-1 cis-dibenzo-1-chloro-8-oxaspiro<7,9>undecan-10-one 
• 83-33-0 inden-1-one 
• 53446-63-2 2-isopropyl-2,3-dihydro-1H-inden-1-one 
• 697-64-3 (R)-indan-1-ol 
• 65738-56-9 methyl 5-chloro-1-oxo-2,3-dihydro-1H-indene-2-carboxylate 
• 54763-67-6 trans-(+)-3'-(4-methylphenyl)spiro(inden-2,2'-oxiran)-1(3H)-one 
• 54763-67-6 trans-(-)-3'-(4-methylphenyl)spiro(inden-2,2'-oxiran)-1(3H)-one 

Relevant articles and documents

Catalytic Enantioselective Protonation of Monofluorinated Silyl Enol Ethers towards Chiral α-Fluoroketones

Described herein is an organocatalytic enantioselective protonation of monofluorinated silyl enol ethers, affording an array of optically active α-secondary α-fluoroketones in good to high yields and enantioselectivities, under the catalysis of bifunction

Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents

A set of α-quaternary 3-chloro-1-hydroxyalkylphosphonates, analogues of fosfomycin and fosfonochlorin, some of which are new compounds, was synthesized. The compounds were screened for bioactivity against several clinical and standard microbial isolates. Some were found to have moderate activity. The activity was higher with phenyl protection of the phosphoryl ester groups and α-phenyl substitution. Compound 11 was as effective or more potent than fosfomycin or chloramphenicol against several Gram-negative bacteria as well as against some Gram-positive ones.

Convincing Catalytic Performance of Oxo-Tethered Ruthenium Complexes for Asymmetric Transfer Hydrogenation of Cyclic α-Halogenated Ketones through Dynamic Kinetic Resolution

A highly efficient dynamic kinetic resolution of cyclic halohydrins was achieved by the asymmetric transfer hydrogenation of racemic α-haloketones. Bifunctional oxo-tethered Ru(II) catalysts could promote the reduction without deterioration of halogens. By structural tuning of the catalyst, chiral alcohols having halogen, ester, carboxamide, and sulfone functions were obtained variably with excellent diastereo- and enantioselectivities (up to >99:1 d.r. and >99.9 ee), which provided a concise synthetic approach to a dopamine D3 receptor ligand, (+)-PHNO.

A Simple and Efficient Method for the Preparation of α-Halogenated Ketones Using Iron(III) Chloride and Iron(III) Bromide as Halogen Sources with Phenyliodonium Diacetate as Oxidant

α-Halogenated ketones are both unique structure moieties existing in biologically natural products and valuable synthetic intermediates for the preparation of functional molecules. An efficient and scalable method for the preparation of α-halogenated ketone using iron (III) chloride and iron (III) bromide as halogen sources with phenyliodonium diacetate as oxidant has been developed, featuring mild reaction conditions, environmentally friendly reagents, and wide substrate scope. Notably, the three-step synthesis of drug prasugrel was achieved using this developed method as a key step with 30% yield on gram-scale. Additionally, the reaction mechanism involving chloride cation was proposed based on some preliminary control experiments. (Figure presented.).