1579511-77-5

Basic information

• Product Name: 2-(4-bromophenyl)-1,3-diazaspiro[4.4]non-1-en-4-one
• Synonyms: 2-(4-bromophenyl)-1,3-diazaspiro[4.4]non-1-en-4-one
• CAS NO: 1579511-77-5
• Molecular Weight: 293.163
• Mol File: 1579511-77-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(4-bromophenyl)-1,3-diazaspiro[4.4]non-1-en-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)-1,3-diazaspiro[4.4]non-1-en-4-one(1579511-77-5)
• EPA Substance Registry System: 2-(4-bromophenyl)-1,3-diazaspiro[4.4]non-1-en-4-one(1579511-77-5)

Safety Data

• Hazardous Substances Data: 1579511-77-5(Hazardous Substances Data)

Upstream product

• 931-17-9 1,2-Cyclohexanediol 
• 55368-42-8 4-bromobenzamidine hydrochloride 
• 586-76-5 4-Bromobenzoic acid 
• 17193-28-1 1-aminocyclopentane-1-carboxamide 
• 1579511-74-2 4-bromo-N-(1-carbamoylcyclopentyl)benzamide 
• 108-94-1 cyclohexanone 
• 15026-77-4 1-formamidocyclopentane-1-carboxylic acid 

Downstream Products

• 1579511-85-5 (R)-2-(4-bromophenyl)-3-(pyrrolidin-3-ylmethyl)-1,3-diazaspiro[4.4]non-1-en-4-one 
• 1579511-89-9 (R)-2-(4-bromophenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1,3-diazaspiro[4.4]non-1-en-4-one 
• 1579511-80-0 (S)-tert-butyl 3-((2-(4-bromophenyl)-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

OMS-2 nanorod-supported cobalt catalyst for aerobic dehydrocyclization of vicinal diols and amidines: Access to functionalized imidazolones

The development of reusable base metal catalysts for innovative catalytic transformations is a key technology toward sustainable production of fine chemicals, pharmaceuticals, and other function products. Herein, we report the preparation of a new highly dipersed manganese oxides of octahedral molecular sieve (OMS-2) nanorod-supported cobalt catalyst, which is successfully applied for aerobic dehydrocyclization of vicinal diols and amidines to access structurally diverse imidazolones, a class of valuable compounds found in numerous natural and biomedical products. The developed catalytic transformation proceeds with broad substrate scope, good functional group compability, the use of green molecular oxygen and reusable cobalt catalyst, which offers an important platform for the conversion of abundant and sustainable alcohol resources into functional N-heterocycles. The strategy combining nanocatalyst design with aerobic dehydrocoupling is anticipated to achieve other challenging catalytic transformations.

Efficient 4,5-dihydro-1H-imidazol-5-one formation from amidines and ketones under transition-metal free conditions?

An efficient procedure for 4,5-dihydro-1H-imidazol-5-one preparation from aryl amidines and ketones under transition-metal free conditions is described. When cyclic ketones were employed, various spiro-fused 4,5-dihydro-1H-imidazol-5-ones were formed in h

IMIDAZOLIN-5-ONE DERIVATIVE USEFUL AS FASN INHIBITORS FOR THE TREATMENT OF CANCER

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including those mediated by inhibition of fatty acid synthase (FASN) enzyme, such as, cancer, obesity or related discorders, and liver related disorders. Such compounds are represented by formula (I) as follows: wherein L1, a, b, m, n, R1, R2, R3, R4, and R5 are defined herein.