157978-01-3

Basic information

• Product Name: bis(acetoxymethyl) <(2,4-dichlorophenoxy)carbonyl>phosphonate
• CAS NO: 157978-01-3
• Molecular Weight: 415.121
• Mol File: 157978-01-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: bis(acetoxymethyl) <(2,4-dichlorophenoxy)carbonyl>phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: bis(acetoxymethyl) <(2,4-dichlorophenoxy)carbonyl>phosphonate(157978-01-3)
• EPA Substance Registry System: bis(acetoxymethyl) <(2,4-dichlorophenoxy)carbonyl>phosphonate(157978-01-3)

Safety Data

• Hazardous Substances Data: 157978-01-3(Hazardous Substances Data)

Upstream product

• 13398-11-3 iodomethyl acetate 
• 42571-78-8 chlorocarbonic acid-(2,4-dichloro-phenyl ester) 
• 157978-04-6 C₁₃H₂₁Cl₂O₅PSi₂ 

Relevant articles and documents

Synthesis, hydrolytic behavior, and anti-HIV activity of selected acyloxyalkyl esters of trisodium phosphonoformate (foscarnet sodium)

The synthesis and anti-HIV activity of selected (acyloxy)-alkyl esters of trisodium phosphonoformate (foscarnet sodium) are described. The conversion of bis(trimethylsilyl) (alkoxycarbonyl)phosphonates 11a-d to the corresponding disilver salts 12a-d and their subsequent reaction with iodoalkyl acrylates 4a-c gave the desired bis(acyloxyalkyl) phosphonates 6- 9(a-c). Of the analogs tested, only the dichlorophenyl analog 9a showed a dose-dependent inhibition of HIV activity in H9 cells. Using 31P-NMR, bioreversibility has been investigated in an attempt to rationalize these results.