158020-74-7

Basic information

• Product Name: Ethyl imidazo[1,2-a]pyridine-8-carboxylate
• Synonyms: Ethyl imidazo[1,2-a]pyridine-8-carboxylate;IMidazo[1,2-a]pyridine-8-carboxylic acid, ethyl ester
• CAS NO: 158020-74-7
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.1986
• Mol File: 158020-74-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethyl imidazo[1,2-a]pyridine-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl imidazo[1,2-a]pyridine-8-carboxylate(158020-74-7)
• EPA Substance Registry System: Ethyl imidazo[1,2-a]pyridine-8-carboxylate(158020-74-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 158020-74-7(Hazardous Substances Data)

Usage

General Description

Ethyl imidazo[1,2-a]pyridine-8-carboxylate is a chemical compound with the molecular formula C11H10N2O2. It is a derivative of imidazo[1,2-a]pyridine, a heterocyclic compound that is commonly used in the synthesis of pharmaceuticals and agrochemicals. This particular ethyl ester derivative is often used as a building block in organic synthesis, particularly in the preparation of potential drug candidates and bioactive molecules. Its unique structure and chemical properties make it a valuable intermediate in the pharmaceutical industry for the development of new medications and therapeutic agents.

Upstream product

• 107-20-0 2-chloroethanal 
• 13362-26-0 2-aminopyridine-3-carboxylic acid ethyl ester 
• 7252-83-7 1-bromo-2,2-dimethoxyethane 

Downstream Products

• 136117-74-3 8-imidazo<1,2-a>pyridinecarboxaldehyde 
• 111477-17-9 8-hydroxymethylimidazo[1,2-a]pyridine 
• 372147-63-2 (Z)-ethyl α-[(triphenylphosphoranylideneamino)-β-(imidazo[1,2-a]pyridin-8-yl)]propenoate 
• 1402911-61-8 C₂₅H₃₃Cl₂N₃O₂Si 
• 1402911-28-7 {8-[({trans-3-[(2,3-dichlorophenyl)oxy]cyclobutyl}amino)methyl]imidazo[1,2-a]pyridin-3-yl}methanol 

Relevant articles and documents

MALIC ENZYME INHIBITORS

The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.

IMIDAZO [1, 2 -A] PYRIDINES AS JNK MODULATORS

Compounds of formula (I) modulate JNK wherein X1 and X2 are each simultaneously N or CH; X3 is CH-R2 Or N-SO2R, where R is lower alkyl; R1 is aryl or heteroaryl, substituted with 0-3 lower

Heterocyclization of functionalized vinylic derivatives of imidazo[1,2-α]pyridines

Heterocyclization of functionalized vinylic derivatives of imidazo[1,2-α]pyridines was explored experimentally and theoretically using semiempirical AM1 and ab initio methods. A range of functionalized vinylic derivatives (azido, amino, and carbodiimide groups) were prepared for conversion into pyrroloazaindoles 19-22, imidazo[1,x]-; (x=5, 6, 7, 8), [2,6]-, and [2,7]naphthyridines 28-30, 35-38 by thermal reaction. In the case of vinylic groups in the 5 position, peri annulation also was observed. The experimental and theoretical data are compared and discussed.