158069-72-8

Basic information

• Product Name: Entacapone-3'-sulfate SodiuM Salt
• Synonyms: Entacapone-3'-sulfate SodiuM Salt
• CAS NO: 158069-72-8
• Molecular Formula: C14H14N3NaO8S
• Molecular Weight: 407.33103
• Product Categories: Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 158069-72-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.561±0.06 g/cm3(Predicted)
• PKA: -5.48±0.18(Predicted)
• CAS DataBase Reference: Entacapone-3'-sulfate SodiuM Salt(CAS DataBase Reference)
• NIST Chemistry Reference: Entacapone-3'-sulfate SodiuM Salt(158069-72-8)
• EPA Substance Registry System: Entacapone-3'-sulfate SodiuM Salt(158069-72-8)

Safety Data

• Hazardous Substances Data: 158069-72-8(Hazardous Substances Data)

Usage

Description

Entacapone-3'-sulfate SodiuM Salt, also known as (E)-Entacapone-3’-sulfate, is a metabolite of Entacapone (E558500). It functions as a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme that plays a crucial role in the metabolism of catecholamine neurotransmitters and related drugs. Entacapone-3'-sulfate SodiuM Salt is particularly relevant in the context of antiparkinsonian treatments due to its ability to modulate the levels of neurotransmitters in the brain.

Uses

Used in Pharmaceutical Industry:
Entacapone-3'-sulfate SodiuM Salt is used as an antiparkinsonian agent for enhancing the therapeutic effects of levodopa in Parkinson's disease patients. By inhibiting the COMT enzyme, it helps to increase the availability and duration of action of dopamine, thereby improving the symptoms and overall quality of life for individuals suffering from Parkinson's disease.
Additionally, Entacapone-3'-sulfate SodiuM Salt may be utilized in research and development for the creation of novel drugs targeting the COMT enzyme, potentially leading to advancements in the treatment of various neurological and psychiatric disorders.