158091-64-6

Basic information

• Product Name: 3-(2,4,6-trimethylphenyl)thio-1H-1,2,4-triazole
• Synonyms: 3-(2,4,6-trimethylphenyl)thio-1H-1,2,4-triazole
• CAS NO: 158091-64-6
• Molecular Formula: C11H13N3S
• Molecular Weight: 219.31
• EINECS: -0
• Mol File: 158091-64-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3-(2,4,6-trimethylphenyl)thio-1H-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,4,6-trimethylphenyl)thio-1H-1,2,4-triazole(158091-64-6)
• EPA Substance Registry System: 3-(2,4,6-trimethylphenyl)thio-1H-1,2,4-triazole(158091-64-6)

Safety Data

• Hazardous Substances Data: 158091-64-6(Hazardous Substances Data)

Usage

Description

3-(2,4,6-Trimethylphenyl)thio-1H-1,2,4-triazole is an organic compound characterized by its triazole ring structure with a thiophene group attached to a trimethylphenyl group. This chemical structure endows it with specific properties that make it useful in various applications.

Uses

Used in Chemical Synthesis:
3-(2,4,6-Trimethylphenyl)thio-1H-1,2,4-triazole is used as an intermediate in the synthesis of other compounds, specifically 3-(2,4,6-Trimethylphenylsulfonyl)-1,2,4-triazole (T482395), which is a key component in the development of certain herbicides.
Used in Agriculture:
In the agricultural industry, 3-(2,4,6-Trimethylphenyl)thio-1H-1,2,4-triazole is used as a precursor for the production of T482395, a herbicide. This herbicide is employed for controlling the growth of unwanted plants and weeds in various crops, thereby improving crop yield and quality.
The compound's role in the synthesis of a herbicide highlights its importance in the chemical and agricultural sectors, where it contributes to the development of effective and targeted weed control solutions.

Upstream product

• 88-05-1 2,4,6-trimethylaniline 
• 576-83-0 2,4,6-trimethylphenyl bromide 
• 3179-31-5 1H-[1,2,4]triazole-3-thiol 
• 4028-63-1 iodomesitylene 

Downstream Products

• 149591-20-8 3-(2,4,6-trimethylphenyl)sulfonyl-1H-1,2,4-triazole 
• 475588-71-7 3-(2,4,6-trimethylphenyl)thio-1-dimethylcarbamoyl-1H-1,2,4-triazole 

Relevant articles and documents

Conversion of 2,4,6-Trimethylaniline to 3-(Mesitylthio)-1 H-1,2,4-triazole Using a Continuous-Flow Reactor

An expeditious and highly efficient continuous-flow process was developed for the synthesis of 3-(mesitylthio)-1H-1,2,4-triazole. The starting material 2,4,6-trimethylaniline was diazotized to give diazonium chloride, followed by azo-coupling with 1H-1,2,4-triazole-3-thiol and dediazoniation to provide 3-(mesitylthio)-1H-1,2,4-triazole in 85% yield with a productivity of 344 g/h. The side reactions such as hydrolysis, dimerization, and intramolecular coupling were significantly inhibited by the continuous-flow technology.

Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials

(Graph Presented) Screening of the GSK corporate collection, some 1.9 million compounds, against Plasmodium falciparum (Pf), revealed almost 14000 active hits that are now known as the Tres Cantos Antimalarial Set (TCAMS). Followup work by Calderon et al.

Pharmaceutical use of N-Carbamoylazole derivatives

The present invention relates to use of 1-carbamoylazole derivatives as medicaments and pharmaceutical compositions containing 1-carbamoylazole derivatives as the active ingredient, based on their DPPIV inhibiting effects. The present invention provides a dipeptidyl peptidase IV inhibiting agent comprising a compound represented by the general formula (I):