15814-97-8Relevant articles and documents
Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/- indanes and structurally modified derivatives: Potent and selective inhibitors of aldosterone synthase
Ulmschneider, Sarah,Müller-Vieira, Ursula,Klein, Christian D.,Antes, Iris,Lengauer, Thomas,Hartmann, Rolf W.
, p. 1563 - 1575 (2005)
Elevated aldosterone levels are key effectors for the development and progression of congestive heart failure and myocardial fibrosis. Recently, we proposed inhibition of aldosterone synthase (CYP11B2) as an innovative strategy for the treatment of these
Catalytic Amide-Base System of TMAF and N(TMS)3 for Deprotonative Coupling of Benzylic C(sp3)-H Bonds with Carbonyls
Shigeno, Masanori,Nakaji, Kunihito,Nozawa-Kumada, Kanako,Kondo, Yoshinori
supporting information, p. 2588 - 2592 (2019/04/25)
This paper describes that an amide-base generated in situ from tetramethylammonium fluoride (TMAF) and N(TMS)3 catalyzes the deprotonative coupling of benzylic C(sp3)-H bonds with carbonyls to form stilbenes. A variety of methylheteroarenes (2-methylbenzothiophene, 2-methylbenzofuran, and 2-, 3-, or 4-methylpyridines) are used as nucleophiles. Application to enamine synthesis using DMF as an electrophile is also shown. The present system is effective for toluenes (4-phenyl-, 4-bromo-, 2-bromo-, and 4-chlorotoluenes) having low reactivity.