158144-80-0

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-formyl-4-phenyl-, 1,1-dimethylethyl ester
• CAS NO: 158144-80-0
• Molecular Formula: C17H23NO3
• Molecular Weight: 289.375
• Mol File: 158144-80-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-formyl-4-phenyl-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-formyl-4-phenyl-, 1,1-dimethylethyl ester(158144-80-0)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-formyl-4-phenyl-, 1,1-dimethylethyl ester(158144-80-0)

Safety Data

• Hazardous Substances Data: 158144-80-0(Hazardous Substances Data)

Usage

Chemical class

t-butyl ester derivative of piperidinecarboxylic acid

Molecular weight

275.39 g/mol

Physical state

white to off-white solid at room temperature

Solubility

soluble in organic solvents such as acetone and ethyl acetate

Uses

organic synthesis, pharmaceutical research, and potential applications in the development of pharmaceutical drugs, as well as other industrial uses.

Upstream product

• 158144-79-7 tert-butyl 4-cyano-4-phenylpiperidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 51304-58-6 4-cyano-4-phenylpiperidine hydrochloride 

Downstream Products

• 167262-68-2 N-(t-butyloxycarbonyl)-4-phenylpiperidine-4-carboxylic acid 
• 716358-34-8 tert-butyl 4-[(E/Z)-2-methoxyethenyl]-4phenylpiperidine-1-carboxylate 
• 1292306-44-5 ethyl 5-(4-phenylpiperidin-4-yl)pentanoate hydrochloride 
• 1292306-46-7 C₂₁H₃₁NO₄ 
• 716360-31-5 tert-butyl 4-(3-oxopropyl)-4-phenylpiperidine-1-carboxylate 
• 1292306-47-8 C₂₃H₃₃NO₄ 
• 1292360-02-1 C₂₃H₃₅NO₄ 
• 167853-55-6 4-[3-(3,5-Bis-trifluoromethyl-phenyl)-3-hydroxy-propyl]-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 167853-54-5 4-[3-(3,5-Bis-trifluoromethyl-phenyl)-3-oxo-propyl]-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 172734-33-7 4-hydroxy-4-phenylpiperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF

The present invention provides a compound of Formula (1) as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.

Discovery of bioavailable 4,4-disubstituted piperidines as potent ligands of the chemokine receptor 5 and inhibitors of the human immunodeficiency virus-1

We describe robust chemical approaches toward putative CCR5 scaffolds designed in our laboratories. Evaluation of analogues in the 125I-[MIP-1β] binding and Ba-L-HOS antiviral assays resulted in the discovery of 64 and 68 in the 4,4-disubstitited piperidine class H, both potent CCR5 ligands (pIC50 = 8.30 and 9.00, respectively) and HIV-1 inhibitors (pIC50 = 7.80 and 7.84, respectively, in Ba-L-HOS assay). In addition, 64 and 68 were bioavailable in rodents, establishing them as lead molecules for further optimization toward CCR5 clinical candidates.

CCR5 ANTAGONISTS AS THERAPEUTIC AGENTS

The present invention relates to compounds of formula (I) or pharmaceutically acceptable derivatives thereof, useful in the treatment or prophylaxis of CCR5-related diseases and disorders, for example, in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).