15816-25-8

Basic information

• Product Name: Benzenecarboximidic acid, 4-(trifluoromethyl)-, ethyl ester, hydrochloride
• Synonyms: 4-trifluoromethyl-benzimidic acid ethyl ester hydrochloride salt;4-Trifluoromethyl-benzimidic acid ethyl ester;4-trifluoromethyl-benzimidic acid ethyl ester, hydrochloride;hydrochloride;p-Trifluormethyl-benzimido-ethylester-hydrochlorid
• CAS NO: 15816-25-8
• Molecular Formula: C10H10F3NO.ClH
• Molecular Weight: 253.652
• Mol File: 15816-25-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzenecarboximidic acid, 4-(trifluoromethyl)-, ethyl ester, hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenecarboximidic acid, 4-(trifluoromethyl)-, ethyl ester, hydrochloride(15816-25-8)
• EPA Substance Registry System: Benzenecarboximidic acid, 4-(trifluoromethyl)-, ethyl ester, hydrochloride(15816-25-8)

Safety Data

• Hazardous Substances Data: 15816-25-8(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 455-18-5 4-CF₃C₆H₄CN 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 66046-34-2 4-(trifluoromethyl)benzaldehyde oxime 
• 75-36-5 acetyl chloride 

Downstream Products

• 38196-04-2 [2-(4-trifluoromethyl-phenyl)-benzooxazol-5-yl]-acetic acid 
• 131472-28-1 4-trifluoromethylbenzamidine 
• 1257531-47-7 N-(ethoxycarbonyl)-4-(trifluoromethyl)benzenehydrazonic acid ethyl ester 
• 1055051-35-8 methyl 2-[4-(trifluoromethyl)phenyl]-1,3-oxazoline-4-carboxylate 
• 753479-58-2 methyl 2-(4-(trifluoromethyl)phenyl)oxazole-4-carboxylate 
• 1370731-52-4 methyl 2-(p-trifluoromethylphenyl)-5-phenyloxazole-4-carboxylate 
• 1370731-69-3 methyl 2-(p-trifluoromethylphenyl)-5-(3,4-dichlorophenyl)oxazole-4-carboxylate 
• 1370731-71-7 methyl 2-(p-trifluoromethylphenyl)-5-(3,5-dichlorophenyl)oxazole-4-carboxylate 
• 1370731-72-8 methyl 2-(p-trifluoromethylphenyl)-5-(2,4-dichlorophenyl)oxazole-4-carboxylate 
• 1370731-76-2 methyl 2-(p-trifluoromethylphenyl)-5-(3-nitrophenyl)oxazole-4-carboxylate 

Relevant articles and documents

Microwave-assisted synthesis and biological evaluation of some benzimidazole derivatives containing a 1,2,4-Triazol Ring

A new series of 2-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole derivatives containing a 1,2,4-triazole ring were synthesized via microwave technique. This efficient procedure provides pure products within a few minutes. The newly synthesized compounds were confirmed by 1H NMR and 13C NMR spectra and they were screened for their lipase inhibition and antioxidant activities. Compounds 4a, 4b, 5a, and 5b showed very good scavenging activity. A series of 2-(4-(trifluoromethyl)phenyl)-1H-benzo[d] imidazole derivatives containing a 1,2,4-triazole ring were synthesized via microwave technique and screened for their lipase inhibition and antioxidant activities. Compounds 4a, 4b, 5a, and 5b showed very good scavenging activity.

Pd(ii)-catalyzed direct C5-arylation of azole-4-carboxylates through double C-H bond cleavage

The first palladium-catalyzed direct C5-arylation of azole-4-carboxylates with simple unactivated arenes through double C-H bond cleavage is realized. This protocol provided a straightforward access to diverse 5-arylsubstituted azole-4-carboxylic derivatives with good functional group tolerance. The Royal Society of Chemistry 2012.

Microwave-assisted synthesis of novel 2,4-dihydro-5-[4-(trifluoromethyl) phenyl]-3h-1,2,4-triazol-3-ones and potentiometric determination of their pKa in nonaqueous solvents

The novel 4-amino- or 4-aryl-substituted 2,4-dihydro-5-[(4-trifluoromethyl) phenyl]-3H-1,2,4-triazol-3-ones 3a-3g were synthesized by reaction of N-(ethoxycarbonyl)-4-(trifluoromethyl)benzenehydrazonic acid ethyl ester (2) and primary amines or hydrazine