1583-65-9Relevant articles and documents
Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus
Menzella, Hugo G.,Tran, Thomas-Toan,Carney, John R.,Lau-Wee, Janice,Galazzo, Jorge,Reeves, Christopher D.,Carreras, Christopher,Mukadam, Sophie,Eng, Sara,Zhong, Ziyang,Timmermans, Pieter B. M. W. M.,Murli, Sumati,Ashley, Gary W.
supporting information; experimental part, p. 1518 - 1521 (2010/02/28)
Inhibition of the protein chaperone Hsp90 is a promising new approach to cancer therapy. We describe the preparation of potent non-benzoquinone ansamycins. One of these analogues, generated by feeding 3-amino-5-chlorobenzoic acid to a genetically engineer
Macrolactams by engineered biosynthesis
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Page/Page column 15, (2008/12/07)
Macrolactams are made by feeding aromatic amino acids as replacement starter units to a mutant strain of the geldanamycin-producing microorganism Streptomyces hygroscopicus var. geldanus NRRL 3602, wherein the gene cluster encoding enzymes for the biosynt
A lockable light-driven molecular shuttle with a fluorescent signal
Wang, Qiao-Chun,Qu, Da-Hui,Ren, Jun,Chen, Kongchang,Tian, He
, p. 2661 - 2665 (2007/10/03)
A turn on! A lockable photodriven molecular shuttle is based on a [2]rotaxane that consists of an α-cyclodextrin threaded by a stilbene derivative. The fluorescent signals originate from the naphthalimide stopper and indicate the position of the shuttle. Once unlocked, the device can be turned on by irradiation at 335 nm and turned off by irradiation at 280 nm. The shuttle can be locked or unlocked by the addition acid or alkali, respectively (see picture).