1583-67-1

Basic information

• Product Name: 3-Fluorophthalic acid
• Synonyms: 3-FLUORO-1,2-BENZENEDICARBOXYLIC ACID;3-FLUOROPHTHALIC ACID;1,2-Benzenedicarboxylic acid, 3-fluoro-;3-Fluorophthalic;3-Fluorophthalic acid 98%;3-Fluorophthalicacid98%;3-fluorobenzene-1,2-dicarboxylic acid;3-Fluorophthalic acid, 98% 5GR
• CAS NO: 1583-67-1
• Molecular Formula: C₈H₅FO₄
• Molecular Weight: 184.12
• EINECS: 216-433-5
• Product Categories: Phthalic Acids, Esters and Derivatives
• Mol File: 1583-67-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 175-177 °C(lit.)
• Boiling Point: 367.9 °C at 760 mmHg
• Flash Point: 176.3 °C
• Appearance: White to light yellow crystal powder
• Density: 1.4111 (estimate)
• Vapor Pressure: 4.63E-06mmHg at 25°C
• Storage Temp.: Store below +30°C.
• PKA: 2.32±0.10(Predicted)
• Water Solubility: Soluble in water
• BRN: 2616684
• CAS DataBase Reference: 3-Fluorophthalic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluorophthalic acid(1583-67-1)
• EPA Substance Registry System: 3-Fluorophthalic acid(1583-67-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1583-67-1(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow crystal powder

InChI:InChI=1/C8H5FO4/c9-5-3-1-2-4(7(10)11)6(5)8(12)13/h1-3H,(H,10,11)(H,12,13)/p-2

Upstream product

• 652-39-1 3-fluorophthalic anhydride 
• 321-38-0 1-Fluoronaphthalene 
• 443-82-3 3-fluoro-o-xylene 
• 87-59-2 2,3-Dimethylaniline 
• 641-70-3 3-nitrophthalic acid anhydride 

Downstream Products

• 652-39-1 3-fluorophthalic anhydride 
• 876291-59-7 4-fluoro-2-phenylindan-1,3-dione 
• 876291-64-4 (4-fluoro-1,3-dioxo-2-phenyl-indan-2-yl)-acetaldehyde 
• 876291-60-0 2-allyl-4-fluoro-2-phenyl-indan-1,3-dione 
• 94802-89-8 2-allyl-2-phenylindene-1,3(2H)-dione 
• 104079-37-0 2-(Formylmethyl)-2-phenyl-1,3-indandion 
• 161747-14-4 3-fluorobenzene-1,2-dicarbaldehyde 
• 183448-41-1 3-fluorophthalic acid, dimethyl ester 
• 455-38-9 3-fluorobenzoic acid 
• 1381875-85-9 [Cd(3-fluorophthalate)(1,3,5-tris(1-imidazolyl)benzene)]*H₂O 
• 1381875-86-0 [Co(3-fluorophthalate)(1,3,5-tris(1-imidazolyl)benzene)]*H₂O 
• 1234363-74-6 C₁₄H₁₉NO₄ 

Relevant articles and documents

CYCLIC PEPTIDE ANALOGS OF MELANOCORTIN AND AMANITIN AND METHODS OF MAKING SUCH

The invention described herein is based in part on the discovery of a protein/peptide crosslink, which introduces fluorescent properties, and which has been applied to synthesize analogues of melanocortin and amanitin as choice peptides to be explored in the context of isoindole peptides. Without limitation, it is expected that those trained in the art of peptide synthesis and stapling would appreciate the consequences of this invention such that other peptides of varied length can be similarly constrained by isoindole staples as featured herein.

A 3 - phthalic acid synthetic method (by machine translation)

The invention discloses a 3 - phthalic acid synthetic method, the raw material 3 - nitrophthalic acid is dissolved by acetyl chloride solvent dehydration is carried out, after the dehydration by the fluorination potassium [...], then adding thionyl chloride to remove the by-product generated in the process of fluoro, purification to obtain the target compound 3 - phthalic acid. The invention relates to 3 - nitrophthalic acid as the synthetic 3 - phthalic acid raw material, the raw material is cheap, simple process, high yield; by adjusting the PH of the method, the product from the sulfolane solvent in very good separation out, solves the high boiling point of the solvent is not easily evaporated difficult; using acetyl chloride as dehydration solvent, not only replacing the drug control acetic anhydride, but also reduces the acetic anhydride in the dehydration process of the acetic acid by-product, mild reaction conditions after processing is simple and convenient. (by machine translation)

On the regioselectivity of metal hydride reductions of 3-substituted phthalic anhydrides

A problem of 3-methoxyphthalide reduction by metal hydrides was reinvestigated. Various effects controlling selectivity of reductions in 3-substituted phthalides were studied, and a qualitative interpretation of the results is now proposed. Methods for obtaining enhanced yields of one or the other lactonic product were developed.