15832-30-1Relevant articles and documents
Synthesis, antibacterial, and antifungal activities of new pyrimidinone derivatives
Cherif, Oussama,Masmoudi, Fatma,Allouche, Fatma,Chabchoub, Fakher,Trigui, Mohamed
, p. 191 - 194 (2015)
An efficient synthesis of new pyrrolopyrimidinones 3a-d and isoxazolopyrimidinones 4a-c from the respective aminocyanopyrroles 1a-d and aminocyanoisoxazoles 2a-c is presented. The synthesized compounds were screened for antimicrobial activity against a panel of bacteria and fungi. Compound 4c exhibits remarkable activity against a broad spectrum of Gram-positive and Gram-negative bacteria and pathogenic fungi.
Design, synthesis, and biological evaluation of N-(4-substituted)-3-phenylisoxazolo[5,4–d]pyrimidin-4-amine derivatives as apoptosis-inducing cytotoxic agents
Bansod, Sapana,Gaikwad, Nikhil Baliram,Garise, Ramana,Godugu, Chandraiah,Mara, Alekhya,Srinivas, Nanduri,Yaddanapudi, Venkata Madhavi
, (2021/08/05)
A library of new 3-phenylisoxazolo[5,4–d]pyrimidines (8–10) was designed based on a scaffold hybridization technique incorporating the important pharmacophoric features of 4-aminopyrimidine and phenyl isoxazole scaffold which is renowned for its BET inhib