15833-75-7

Basic information

• Product Name: Furan, tetrahydro-3,3-dimethyl-
• CAS NO: 15833-75-7
• Molecular Formula: C6H12O
• Molecular Weight: 100.161
• Mol File: 15833-75-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Furan, tetrahydro-3,3-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Furan, tetrahydro-3,3-dimethyl-(15833-75-7)
• EPA Substance Registry System: Furan, tetrahydro-3,3-dimethyl-(15833-75-7)

Safety Data

• Hazardous Substances Data: 15833-75-7(Hazardous Substances Data)

Upstream product

• 75-83-2 2,2-Dimethylbutane 
• 6921-35-3 3,3-dimethyloxetane 
• 463-51-4 Ketene 
• 76-35-7 2,2-dimethyl-1,3-butanediol 

Downstream Products

• 118793-19-4 (2,2-Dimethyl-4-phenylselanyl-butoxy)-trimethyl-silane 
• 3437-30-7 3,3-dimethylpyrrolidine 

Relevant articles and documents

Toward Orally Absorbed Prodrugs of the Antibiotic Aztreonam. Design of Novel Prodrugs of Sulfate Containing Drugs. Part 2

Aztreonam, first discovered in 1980, is an FDA approved, intravenous, monocyclic beta-lactam antibiotic. Aztreonam is active against Gram-negative bacteria and is still used today. The oral bioavailability of aztreonam in humans is less than 1%. Herein we describe the design and synthesis of potential oral prodrugs of aztreonam.

Chemical Activation Study of the Reactions of Methylene with Oxetan and 3,3-Dimethyloxetan

Methylene (singlet) formed by the photolysis of ketene (313 nm) reacts with oxetan to yield 2-methyl- and 3-methyloxetans by insertion in the C-H bonds and probably also tetrahydrofuran.These products are formed chemically activated and undergo unimolecular decomposition unless collisionally stabilized.Using perfluoropropane as the bath gas, the results obtained with 2-methyloxetan have been interpreted using RRKM theory and a step-ladder model with a most probable step size of ca. 9 kJ mol-1.Using 206 nm radiation yields methylene with excess energy, some of which is still present when it reacts, and results in the production of 2-methyloxetan with an average lifetime approximately one-half that of the energised molecule produced when 313 nm radiation is used.Similarly methylene reacts with 3,3-dimethyloxetan to yield chemically activated 3-ethyl-3-methyloxetan and 2,3,3-trimethyloxetan.A third compound tentatively identified as 3,3-dimethyltetrahydrofuran is also formed.The decomposition of these 3 molecules has been followed and in the case of the ethylmethyloxetan the average energy transferred in collision with 3,3-dimethyloxetan has been found to be ca. 6.5 kJ mol-1.Some deductions can be made about the Arrhenius parameters for the thermal decomposition of the (as yet unreported) trimethyloxetan and the dimethyltetrahydrofuran.