158365-49-2Relevant articles and documents
Synthesis of sulfonamides and evaluation of their histone deacetylase (HDAC) activity
Oh, Seikwan,Moon, Hyung-In,Son, Il-Hong,Jung, Jae-Chul
, p. 1125 - 1135 (2007)
A simple synthesis of sulfonamides 4-22 as novel histone deacetylase (HDAC) inhibitors is described. The key synthetic strategies involve N-sulfonylation of L-proline benzyl ester hydrochloride (2) and coupling reaction of N-sulfonyl chloride 3 with amine
Compounds, compositions, and methods for stimulating neuronal growth and elongation
-
, (2008/06/13)
The present invention concerns methods, pharmaceutical compounds, and compositions for stimulating neuroite outgrowth in nerve cells leading to nerve regeneration. These methods, compounds and compositions inhibit rotamase enzyme activity associated with binding proteins.